BACKGROUND: The presence of specific and common genetic etiologies for autism spectrum disorders (ASD) and attention-deficit/hyperactivity disorder (ADHD) was investigated for 132 candidate genes in a two-stage design-association study. METHODS: 1,536 single nucleotide polymorphisms (SNPs) covering these candidate genes were tested in ASD (n = 144) and ADHD (n = 110) patients and control subjects (n = 404) from The Netherlands. A second stage was performed with those SNPs from Stage I reaching a significance threshold for association of p < .01 in an independent sample of ASD patients (n = 128) and controls (n = 124) from the United Kingdom and a Dutch ADHD (n = 150) and control (n = 149) sample. RESULTS: No shared association was found between ASD and ADHD. However, in the first and second ASD samples and in a joint statistical analysis, a significant association between SNP rs167771 located in the DRD3 gene was found (joint analysis uncorrected: p = 3.11 x 10(-6); corrected for multiple testing and potential stratification: p = .00162). CONCLUSIONS: The DRD3 gene is related to stereotyped behavior, liability to side effects of antipsychotic medication, and movement disorders and may therefore have important clinical implications for ASD.
BACKGROUND: The presence of specific and common genetic etiologies for autism spectrum disorders (ASD) and attention-deficit/hyperactivity disorder (ADHD) was investigated for 132 candidate genes in a two-stage design-association study. METHODS: 1,536 single nucleotide polymorphisms (SNPs) covering these candidate genes were tested in ASD (n = 144) and ADHD (n = 110) patients and control subjects (n = 404) from The Netherlands. A second stage was performed with those SNPs from Stage I reaching a significance threshold for association of p < .01 in an independent sample of ASDpatients (n = 128) and controls (n = 124) from the United Kingdom and a Dutch ADHD (n = 150) and control (n = 149) sample. RESULTS: No shared association was found between ASD and ADHD. However, in the first and second ASD samples and in a joint statistical analysis, a significant association between SNP rs167771 located in the DRD3 gene was found (joint analysis uncorrected: p = 3.11 x 10(-6); corrected for multiple testing and potential stratification: p = .00162). CONCLUSIONS: The DRD3 gene is related to stereotyped behavior, liability to side effects of antipsychotic medication, and movement disorders and may therefore have important clinical implications for ASD.
Authors: Erika J Wolf; Karen S Mitchell; Mark W Logue; Clinton T Baldwin; Annemarie F Reardon; Alison Aiello; Sandro Galea; Karestan C Koenen; Monica Uddin; Derek Wildman; Mark W Miller Journal: J Trauma Stress Date: 2014-08
Authors: Paul A Constable; Sebastian B Gaigg; Dermot M Bowler; Herbert Jägle; Dorothy A Thompson Journal: Doc Ophthalmol Date: 2016-02-11 Impact factor: 2.379
Authors: Nanda N J Rommelse; Barbara Franke; Hilde M Geurts; Catharina A Hartman; Jan K Buitelaar Journal: Eur Child Adolesc Psychiatry Date: 2010-02-11 Impact factor: 4.785
Authors: P J Hamilton; N G Campbell; S Sharma; K Erreger; F Herborg Hansen; C Saunders; A N Belovich; M A Sahai; E H Cook; U Gether; H S McHaourab; H J G Matthies; J S Sutcliffe; A Galli Journal: Mol Psychiatry Date: 2013-08-27 Impact factor: 15.992