AIM: To determine, by counting micronucleus (MN) frequencies, whether chromosomal or DNA damage have an effect on the pathogenesis of early colorectal adenocarcinoma (CRC). METHODS: We analyzed MN frequencies in 21 patients with CRC, 24 patients with colon polyps [10 neoplastic polyps (NP) and 14 non-neoplastic polyps (NNP)] and 20 normal controls. RESULTS: MN frequency was significantly increased in CRC patients and in NP patients compared with controls (3.72 +/- 1.34, 3.58 +/- 1.21 vs 1.97 +/- 0.81, P < 0.001). However, there was no difference in the MN frequency between CRC patients and NP patients (P > 0.05). Similarly, there was no difference in the MN frequency between NNP patients (2.06 +/- 0.85) and controls (P > 0.05). CONCLUSION: Our results suggest increased chromosome/DNA instabilities may be associated with the pathogenesis of early CRC.
AIM: To determine, by counting micronucleus (MN) frequencies, whether chromosomal or DNA damage have an effect on the pathogenesis of early colorectal adenocarcinoma (CRC). METHODS: We analyzed MN frequencies in 21 patients with CRC, 24 patients with colon polyps [10 neoplastic polyps (NP) and 14 non-neoplastic polyps (NNP)] and 20 normal controls. RESULTS: MN frequency was significantly increased in CRC patients and in NP patients compared with controls (3.72 +/- 1.34, 3.58 +/- 1.21 vs 1.97 +/- 0.81, P < 0.001). However, there was no difference in the MN frequency between CRC patients and NP patients (P > 0.05). Similarly, there was no difference in the MN frequency between NNP patients (2.06 +/- 0.85) and controls (P > 0.05). CONCLUSION: Our results suggest increased chromosome/DNA instabilities may be associated with the pathogenesis of early CRC.
Authors: Frederik Jan Van Schooten; Ahmad Besaratinia; Ahmad Besarati Nia; Silvio De Flora; Francesco D'Agostini; Alberto Izzotti; Anna Camoirano; Alfons J M Balm; Jan Willem Dallinga; Aalt Bast; Guido R M M Haenen; Laura Van't Veer; Paul Baas; Harumasa Sakai; Nico Van Zandwijk Journal: Cancer Epidemiol Biomarkers Prev Date: 2002-02 Impact factor: 4.254
Authors: Mirela E Ionescu; Mihai Ciocirlan; Gabriel Becheanu; Tudor Nicolaie; Cristina Ditescu; Adriana G Teiusanu; Serban I Gologan; Tudor Arbanas; Mircea M Diculescu Journal: Maedica (Bucur) Date: 2011-07
Authors: Sanjeevani Arora; Hong Yan; Iltaeg Cho; Hua-Ying Fan; Biao Luo; Xiaowu Gai; Dale L Bodian; Joseph G Vockley; Yan Zhou; Elizabeth A Handorf; Brian L Egleston; Mark D Andrake; Emmanuelle Nicolas; Ilya G Serebriiskii; Timothy J Yen; Michael J Hall; Erica A Golemis; Greg H Enders Journal: Gastroenterology Date: 2015-09-05 Impact factor: 22.682