BACKGROUND: Neurofilaments are major structural elements of neuronal cells. The light subunit of neurofilament triplet protein (NFL) has been shown to be increased in several neurological diseases (e.g. vascular, infectious, neurodegenerative), indicating axonal damage. METHODS: In this study we analyzed the NFL levels in all (N=35) available cerebrospinal fluid (CSF) samples from a clinical trial in Huntington's disease (HD) and compared them to age and gender matched controls. RESULTS: The CSF-NFL levels were significantly higher in HD subjects compared with age and genders matched controls, and were correlated with scores on the Unified Huntington's Disease Rating Scale Total Functional Capacity assessment. The potential of CSF-NFL levels as a disease activity marker in HD needs to be further investigated.
BACKGROUND: Neurofilaments are major structural elements of neuronal cells. The light subunit of neurofilament triplet protein (NFL) has been shown to be increased in several neurological diseases (e.g. vascular, infectious, neurodegenerative), indicating axonal damage. METHODS: In this study we analyzed the NFL levels in all (N=35) available cerebrospinal fluid (CSF) samples from a clinical trial in Huntington's disease (HD) and compared them to age and gender matched controls. RESULTS: The CSF-NFL levels were significantly higher in HD subjects compared with age and genders matched controls, and were correlated with scores on the Unified Huntington's Disease Rating Scale Total Functional Capacity assessment. The potential of CSF-NFL levels as a disease activity marker in HD needs to be further investigated.
Authors: Edward J Wild; Roberto Boggio; Douglas Langbehn; Nicola Robertson; Salman Haider; James R C Miller; Henrik Zetterberg; Blair R Leavitt; Rainer Kuhn; Sarah J Tabrizi; Douglas Macdonald; Andreas Weiss Journal: J Clin Invest Date: 2015-04-06 Impact factor: 14.808
Authors: Nicholas S Caron; Raul Banos; Christopher Yanick; Amirah E Aly; Lauren M Byrne; Ethan D Smith; Yuanyun Xie; Stephen E P Smith; Nalini Potluri; Hailey Findlay Black; Lorenzo Casal; Seunghyun Ko; Daphne Cheung; Hyeongju Kim; Ihn Sik Seong; Edward J Wild; Ji-Joon Song; Michael R Hayden; Amber L Southwell Journal: J Neurosci Date: 2020-12-11 Impact factor: 6.167
Authors: Filipe B Rodrigues; Lauren M Byrne; Rosanna Tortelli; Eileanoir B Johnson; Peter A Wijeratne; Marzena Arridge; Enrico De Vita; Naghmeh Ghazaleh; Richard Houghton; Hannah Furby; Daniel C Alexander; Sarah J Tabrizi; Scott Schobel; Rachael I Scahill; Amanda Heslegrave; Henrik Zetterberg; Edward J Wild Journal: Sci Transl Med Date: 2020-12-16 Impact factor: 17.956
Authors: Thomas E Angel; Jon M Jacobs; Serena S Spudich; Marina A Gritsenko; Dietmar Fuchs; Teri Liegler; Henrik Zetterberg; David G Camp; Richard W Price; Richard D Smith Journal: Clin Proteomics Date: 2012-03-20 Impact factor: 3.988
Authors: Tua Vinther-Jensen; Lars Börnsen; Esben Budtz-Jørgensen; Cecilie Ammitzbøll; Ida U Larsen; Lena E Hjermind; Finn Sellebjerg; Jørgen E Nielsen Journal: Neurol Neuroimmunol Neuroinflamm Date: 2016-09-28
Authors: Lauren M Byrne; Filipe B Rodrigues; Kaj Blennow; Alexandra Durr; Blair R Leavitt; Raymund A C Roos; Rachael I Scahill; Sarah J Tabrizi; Henrik Zetterberg; Douglas Langbehn; Edward J Wild Journal: Lancet Neurol Date: 2017-06-07 Impact factor: 44.182