| Literature DB >> 19056248 |
W Cahn1, M Rais, F P Stigter, N E M van Haren, E Caspers, H E Hulshoff Pol, Z Xu, H G Schnack, R S Kahn.
Abstract
The underlying mechanisms explaining brain volume changes in schizophrenia are not yet understood, but psychosis might be related to these changes. Forty-eight patients with first-episode schizophrenia underwent Magnetic Resonance Imaging brain scanning at inclusion and after five years. An association was found between longer duration of psychosis, larger gray matter volume decrease and larger ventricular volume increase. These findings strongly suggest that psychosis contributes to brain volume reductions found in schizophrenia.Entities:
Mesh:
Year: 2008 PMID: 19056248 DOI: 10.1016/j.euroneuro.2008.10.006
Source DB: PubMed Journal: Eur Neuropsychopharmacol ISSN: 0924-977X Impact factor: 4.600