AIM: to investigate the relationship between peripheral blood eosinophil count and history of allergy with CAD. METHODS: in a case-control study in Ali-ebn-Abitaleb Educational Hospital of Rafsanjan, Iran, 190 individuals(95 with CAD and 95 without CAD) with mean age of 59.4 +/- 12.6 were investigated. Eosinophil count in peripheral blood, eosinophil leukocyte ratio, neutrophil count and neutrophil/leukocyte ratio were measured. A history of allergy was taken from the participants. RESULTS: there were no significant differences in sex and age among two groups. The mean leukocyte count was 8802.6 +/- 253.3 and 3813.7 +/- 351.9 for case and control groups,respectively; that is, a statistically significant difference,(p<0.05). Eosinophil percent was 1.43% and 0.88% in case and control groups, respectively and this parameter was also significantly higher in case group. History of allergy was not different between the 2 groups. Elevated numbers of eosinophils were observed in Iranian patients with CAD. CONCLUSION: the present results support the theory that eosinophils may have a role in the pathogenesis of ischemic heart disease.
AIM: to investigate the relationship between peripheral blood eosinophil count and history of allergy with CAD. METHODS: in a case-control study in Ali-ebn-Abitaleb Educational Hospital of Rafsanjan, Iran, 190 individuals(95 with CAD and 95 without CAD) with mean age of 59.4 +/- 12.6 were investigated. Eosinophil count in peripheral blood, eosinophil leukocyte ratio, neutrophil count and neutrophil/leukocyte ratio were measured. A history of allergy was taken from the participants. RESULTS: there were no significant differences in sex and age among two groups. The mean leukocyte count was 8802.6 +/- 253.3 and 3813.7 +/- 351.9 for case and control groups,respectively; that is, a statistically significant difference,(p<0.05). Eosinophil percent was 1.43% and 0.88% in case and control groups, respectively and this parameter was also significantly higher in case group. History of allergy was not different between the 2 groups. Elevated numbers of eosinophils were observed in Iranian patients with CAD. CONCLUSION: the present results support the theory that eosinophils may have a role in the pathogenesis of ischemic heart disease.