Literature DB >> 19053845

A synthetically simple, click-generated cyclam-based zinc(II) sensor.

Emiliano Tamanini1, Arna Katewa, Lisa M Sedger, Matthew H Todd, Michael Watkinson.   

Abstract

A cyclam-based macrocyclic sensor has been prepared using synthetically simple "click" chemistry to link a fluorophore to the macrocyclic receptor. This sensor shows high selectivity for Zn(II) over a range of other metals, providing a significant enhancement of fluorescence intensity over a wide pH range. As such, this is the first cyclam-based sensor demonstrated to be selective for Zn(II) and is the first example of a triazole being used as a coordinating ligand on an azamacrocycle. The sensor can access biologically available zinc in mammalian cells, sensing the Zn(II) flux that exists during apoptotic cell death.

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Year:  2009        PMID： 19053845     DOI： 10.1021/ic8017634

Source DB:  PubMed          Journal:  Inorg Chem        ISSN： 0020-1669            Impact factor:   5.165


  17 in total

1.  Zn(II)-coordination modulated ligand photophysical processes - the development of fluorescent indicators for imaging biological Zn(II) ions.

Authors:  Lei Zhu; Zhao Yuan; J Tyler Simmons; Kesavapillai Sreenath
Journal:  RSC Adv       Date:  2014-01-01       Impact factor: 3.361

2.  Integrated and passive 1,2,3-triazolyl groups in fluorescent indicators for zinc(II) ions: thermodynamic and kinetic evaluations.

Authors:  J Tyler Simmons; John R Allen; Deborah R Morris; Ronald J Clark; Cathy W Levenson; Michael W Davidson; Lei Zhu
Journal:  Inorg Chem       Date:  2013-04-26       Impact factor: 5.165

3.  Phosphorescent sensor for biological mobile zinc.

Authors:  Youngmin You; Sumin Lee; Taehee Kim; Kei Ohkubo; Weon-Sik Chae; Shunichi Fukuzumi; Gil-Ja Jhon; Wonwoo Nam; Stephen J Lippard
Journal:  J Am Chem Soc       Date:  2011-10-24       Impact factor: 15.419

4.  A Highly Selective and Sensitive Peptide-Based Fluorescent Ratio Sensor for Ag.

Authors:  Shuaibing Yu; Zhaolu Wang; Lei Gao; Bo Zhang; Lei Wang; Jinming Kong; Lianzhi Li
Journal:  J Fluoresc       Date:  2020-11-20       Impact factor: 2.217

Review 5.  Imaging mobile zinc in biology.

Authors:  Elisa Tomat; Stephen J Lippard
Journal:  Curr Opin Chem Biol       Date:  2010-01-22       Impact factor: 8.822

Review 6.  Review on Recent Advances in Metal Ions Sensing Using Different Fluorescent Probes.

Authors:  Suman Chowdhury; Bipin Rooj; Ankita Dutta; Ujjwal Mandal
Journal:  J Fluoresc       Date:  2018-07-14       Impact factor: 2.217

7.  Polyamide-scorpion cyclam lexitropsins selectively bind AT-rich DNA independently of the nature of the coordinated metal.

Authors:  Anthony T S Lo; Noeris K Salam; David E Hibbs; Peter J Rutledge; Matthew H Todd
Journal:  PLoS One       Date:  2011-05-09       Impact factor: 3.240

8.  Incorporating a piperidinyl group in the fluorophore extends the fluorescence lifetime of click-derived cyclam-naphthalimide conjugates.

Authors:  Mingfeng Yu; Sandra Ast; Qun Yu; Anthony T S Lo; Roman Flehr; Matthew H Todd; Peter J Rutledge
Journal:  PLoS One       Date:  2014-07-01       Impact factor: 3.240

9.  Biologically targeted probes for Zn2+: a diversity oriented modular "click-SNAr-click" approach†Electronic supplementary information (ESI) available: Full experimental details including characterisation of all novel compounds can be found in the ESI. See DOI: 10.1039/c4sc01249f.

Authors:  J Pancholi; D J Hodson; K Jobe; G A Rutter; S M Goldup; M Watkinson
Journal:  Chem Sci       Date:  2014-06-27       Impact factor: 9.825

10.  Incorporation of Bulky and Cationic Cyclam-Triazole Moieties into Marimastat Can Generate Potent MMP Inhibitory Activity without Inducing Cytotoxicity.

Authors:  Mingfeng Yu; Ngee H Lim; Samantha Ellis; Hideaki Nagase; James A Triccas; Peter J Rutledge; Matthew H Todd
Journal:  ChemistryOpen       Date:  2013-06-12       Impact factor: 2.911
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