Literature DB >> 19053720

In situ "click" assembly of small molecule matrix metalloprotease inhibitors containing zinc-chelating groups.

Mingyu Hu1, Junqi Li, Shao Q Yao.   

Abstract

A panel of small molecule-based MMP inhibitors containing rhodanine warheads was assembled using "one-pot" click chemistry. Upon biological screening, moderate inhibitors were identified which specifically targets MMP-7 and MMP-13 over other MMPs.

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Year:  2008        PMID： 19053720     DOI： 10.1021/ol802286g

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  11 in total

1.  Identifying chelators for metalloprotein inhibitors using a fragment-based approach.

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Journal:  J Med Chem       Date:  2010-12-28       Impact factor: 7.446

2.  Conventional and microwave-assisted synthesis of new indole-tethered benzimidazole-based 1,2,3-triazoles and evaluation of their antimycobacterial, antioxidant and antimicrobial activities.

Authors:  Dongamanti Ashok; Srinivas Gundu; Vikas Kumar Aamate; Mohan Gandhi Devulapally
Journal:  Mol Divers       Date:  2018-04-18       Impact factor: 2.943

3.  Merging antimicrobial and visible emission properties within 1,3,4-trisubstituted-1,2,3-triazolium salts.

Authors:  Connor A Lejcher; Eric M Villa; James T Fletcher
Journal:  Med Chem Res       Date:  2022-02-05       Impact factor: 2.351

4.  Structure-Based Bioisosterism Design, Synthesis, Biological Evaluation and In Silico Studies of Benzamide Analogs as Potential Anthelmintics.

Authors:  Franco Vairoletti; Margot Paulino; Graciela Mahler; Gustavo Salinas; Cecilia Saiz
Journal:  Molecules       Date:  2022-04-20       Impact factor: 4.927

5.  Synthesis of many different types of organic small molecules using one automated process.

Authors:  Junqi Li; Steven G Ballmer; Eric P Gillis; Seiko Fujii; Michael J Schmidt; Andrea M E Palazzolo; Jonathan W Lehmann; Greg F Morehouse; Martin D Burke
Journal:  Science       Date:  2015-03-13       Impact factor: 47.728

6.  Identification and characterization of novel inhibitors of Mammalian aspartyl aminopeptidase.

Authors:  Yuanyuan Chen; Hong Tang; William Seibel; Ruben Papoian; Ki Oh; Xiaoyu Li; Jianye Zhang; Marcin Golczak; Krzysztof Palczewski; Philip D Kiser
Journal:  Mol Pharmacol       Date:  2014-06-09       Impact factor: 4.436

7.  Antitumor evaluation of novel phenothiazine derivatives that inhibit migration and tubulin polymerization against gastric cancer MGC-803 cells.

Authors:  Nan Liu; Zhe Jin; Jing Zhang; Jianjun Jin
Journal:  Invest New Drugs       Date:  2018-10-22       Impact factor: 3.850

8.  Triazole-dithiocarbamate based selective lysine specific demethylase 1 (LSD1) inactivators inhibit gastric cancer cell growth, invasion, and migration.

Authors:  Yi-Chao Zheng; Ying-Chao Duan; Jin-Lian Ma; Rui-Min Xu; Xiaolin Zi; Wen-Lei Lv; Meng-Meng Wang; Xian-Wei Ye; Shun Zhu; David Mobley; Yan-Yan Zhu; Jun-Wei Wang; Jin-Feng Li; Zhi-Ru Wang; Wen Zhao; Hong-Min Liu
Journal:  J Med Chem       Date:  2013-11-01       Impact factor: 7.446

9.  Ciprofloxacin-Tethered 1,2,3-Triazole Conjugates: New Quinolone Family Compounds to Upgrade Our Antiquated Approach against Bacterial Infections.

Authors:  Alka Agarwal; Preeti Singh; Anand Maurya; Upendra Kumar Patel; Alka Singh; Gopal Nath
Journal:  ACS Omega       Date:  2022-01-11

10.  Identification of highly selective and potent histone deacetylase 3 inhibitors using click chemistry-based combinatorial fragment assembly.

Authors:  Takayoshi Suzuki; Yuki Kasuya; Yukihiro Itoh; Yosuke Ota; Peng Zhan; Kaori Asamitsu; Hidehiko Nakagawa; Takashi Okamoto; Naoki Miyata
Journal:  PLoS One       Date:  2013-07-16       Impact factor: 3.240
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