| Literature DB >> 19053513 |
Ngoc Tuan Nguyen1, Van Cuong Pham, Marc Litaudon, Françoise Guéritte, Philippe Grellier, Van Tuyen Nguyen, Van Hung Nguyen.
Abstract
Two new alkaloids, desmorostratine (1) and discretine N-oxide (2), were isolated from the stem bark of Desmos rostrata, together with five known alkaloids, discretine (3), dehydrodiscretine (4), pseudocolumbamine (5), predicentrine (6), and aristolactam AII (7). The structures were established on the basis of spectroscopic data, including mass spectrometry and 2D-NMR. Compound 1 was cytotoxic against KB cells (IC(50) 2.4 microM), while 2, 3, and 4 inhibited Plasmodium falciparum (IC(50) of 4.2, 1.6, and 0.9 microM, respectively).Entities:
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Year: 2008 PMID： 19053513 DOI： 10.1021/np8004437
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050