| Literature DB >> 19053509 |
Milton Nascimento da Silva1, Mara Silvia Pinheiro Arruda, Kelly Christina F Castro, M Fátima das G F da Silva, João B Fernandes, Paulo C Vieira.
Abstract
Species of Swietenia elaborate limonoid chemistry along only one route, which leads to the mexicanolide type in most species and the phragmalin type in S. mahogani. A hexane extract from leaves of S. macrophylla afforded six new phragmalins with a 8,9,30-ortho-ester unit, namely, 6-O-acetylswietephragmin E (1), 3beta-O-destigloyl-3beta-O-benzoyl-6-O-acetylswietephragmin E (2), 12alpha-acetoxyswietephragmin C (3), 3beta-O-destigloyl-3beta-O-benzoyl-12alpha-acetoxyswietephragmin C (4), 12alpha-acetoxyswietephragmin D (5), and 3beta-O-destigloyl-3beta-O-benzoyl-12alpha-acetoxyswietephragmin D (6). This appears to be the first record of phragamalins from S. macrophylla, and this study shows the potential of tricyclic [3.3.1(2,10).1(1,4)]-decane limonoids as taxonomically useful chemical markers in the Meliaceae.Entities:
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Year: 2008 PMID： 19053509 DOI： 10.1021/np800312h
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050