| Literature DB >> 19053507 |
D Craig Hopp1, Dennis J Milanowski, Joshua Rhea, Daniel Jacobsen, John Rabenstein, Chris Smith, Khadidja Romari, Midori Clarke, Linda Francis, Macarena Irigoyen, Michele Luche, Grant J Carr, Ulla Mocek.
Abstract
Two new xanthone antibiotics, citreamicin delta (1) and epsilon (2), with potent activity against Gram-positive pathogens including multidrug-resistant Staphylococcus aureus (MDRSA) were discovered. Compounds 1 and 2 exhibited MIC values < 1 microg/mL versus a number of resistant strains. The compounds were obtained from EtOAc extracts of Streptomyces vinaceus and were purified by countercurrent chromatography and reversed-phase HPLC. Their structures were elucidated using primarily NMR and mass spectroscopy.Entities:
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Year: 2008 PMID： 19053507 DOI： 10.1021/np800503z
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050