Literature DB >> 19053325

A new hammer in the redox toolbox: high-purity peroxynitrite for cell signaling and toxicology studies.

Steven R Woodcock1, Bruce A Freeman.   

Abstract

A new chemical synthesis has been disclosed for the oxidizing and nitrating species peroxynitrite. This nitric oxide and superoxide-derived cell signaling mediator can also serve as a toxicant at higher rates of generation. The new synthetic strategy reported by Sturzbecher-Höhne and colleagues overcomes long-standing issues with purity and quality of peroxynitrite preparations and should lay a foundation for nailing new insight into the redox reactions of peroxynitrite and its products.

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Year:  2008        PMID： 19053325      PMCID： PMC4074876          DOI： 10.1021/tx8004136

Source DB:  PubMed          Journal:  Chem Res Toxicol        ISSN： 0893-228X            Impact factor:   3.739


  6 in total

Review 1.  Synthesis of peroxynitrite by azide-ozone reaction.

Authors:  R M Uppu; G L Squadrito; R Cueto; W A Pryor
Journal:  Methods Enzymol       Date:  1996       Impact factor: 1.600

2.  Synthesis of peroxynitrite from nitrite and hydrogen peroxide.

Authors:  Kristine M Robinson; Joseph S Beckman
Journal:  Methods Enzymol       Date:  2005       Impact factor: 1.600

3.  Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

Authors:  J S Beckman; T W Beckman; J Chen; P A Marshall; B A Freeman
Journal:  Proc Natl Acad Sci U S A       Date:  1990-02       Impact factor: 11.205

4.  The emerging biology of the nitrite anion.

Authors:  Mark T Gladwin; Alan N Schechter; Daniel B Kim-Shapiro; Rakesh P Patel; Neil Hogg; Sruti Shiva; Richard O Cannon; Malte Kelm; David A Wink; Michael Graham Espey; Edward H Oldfield; Ryszard M Pluta; Bruce A Freeman; Jack R Lancaster; Martin Feelisch; Jon O Lundberg
Journal:  Nat Chem Biol       Date:  2005-11       Impact factor: 15.040

Review 5.  Peroxynitrite: biochemistry, pathophysiology and development of therapeutics.

Authors:  Csaba Szabó; Harry Ischiropoulos; Rafael Radi
Journal:  Nat Rev Drug Discov       Date:  2007-08       Impact factor: 84.694

6.  Preparation and properties of lithium and sodium peroxynitrite.

Authors:  Manuel Sturzbecher-Höhne; Reinhard Kissner; Thomas Nauser; Willem H Koppenol
Journal:  Chem Res Toxicol       Date:  2008-12       Impact factor: 3.739
  6 in total

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