Literature DB >> 1905306

Role of elevated monocyte transforming growth factor beta (TGF beta) production in posttrauma immunosuppression.

C L Miller-Graziano1, G Szabo, K Griffey, B Mehta, K Kodys, D Catalano.   

Abstract

We previously reported that increased production of prostaglandin E2 by monocytes is a pivotal mechanism in posttrauma immunopathology. Here we characterize monocyte levels of transforming growth factor beta and examine the effects of elevated transforming growth factor beta on prostaglandin E2 release by patients' monocytes. Trauma patients' and normals' monocyte supernates (+/- stimulation with muramyl dipeptide) were acid treated and assayed for transforming growth factor beta using the mink lung-cell bioassay. Alternatively, human transforming growth factor beta was added to patients' and normals' monocytes and prostaglandin E2 production assayed. Significantly elevated transforming growth factor beta levels (median = 181.7 pmol/10(6) monocytes) were detected in immunosuppressed patients' monocytes but not immunocompetent trauma patients' (median = 32.0 pM) or normals' (median = 20.4 pM) monocytes. Adding transforming growth factor beta to monocytes resulted in a significant elevation of prostaglandin E2 levels. Elevated monocyte transforming growth factor beta levels in trauma patients could be both suppressing T-lymphocyte functions and maintaining elevated monocyte prostaglandin E2 synthesis.

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Year:  1991        PMID： 1905306     DOI： 10.1007/bf00917745

Source DB:  PubMed          Journal:  J Clin Immunol        ISSN： 0271-9142            Impact factor:   8.317


  32 in total

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Journal:  J Immunol       Date:  1989-06-15       Impact factor: 5.422

5.  Transforming growth factor-beta 1 (TGF-beta 1) and recombinant human tumor necrosis factor-alpha reciprocally regulate the generation of lymphokine-activated killer cell activity. Comparison between natural porcine platelet-derived TGF-beta 1 and TGF-beta 2, and recombinant human TGF-beta 1.

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Journal:  J Immunol       Date:  1988-04-01       Impact factor: 5.422

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Journal:  Arch Surg       Date:  1988-03

9.  Transforming growth factor-beta is a potent immunosuppressive agent that inhibits IL-1-dependent lymphocyte proliferation.

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Journal:  J Immunol       Date:  1988-05-01       Impact factor: 5.422

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Authors:  G E Ranges; I S Figari; T Espevik; M A Palladino
Journal:  J Exp Med       Date:  1987-10-01       Impact factor: 14.307
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  23 in total

Review 1.  Mechanisms of immune resolution.

Authors:  Alfred Ayala; Chun-Shiang Chung; Patricia S Grutkoski; Grace Y Song
Journal:  Crit Care Med       Date:  2003-08       Impact factor: 7.598

2.  PATHOLOGICAL ASPECTS OF THE ANTI-INFLAMMATORY/IMMUNE SUPPRESSIVE RESPONSE IN SEPSIS AND SHOCK.

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Journal:  Rec Res Dev Immunol       Date:  2003-01-12

3.  Pathogen-reduced PRP blocks T-cell activation, induces Treg cells, and promotes TGF-β expression by cDCs and monocytes in mice.

Authors:  Johnson Q Tran; Marcus O Muench; Rachael P Jackman
Journal:  Blood Adv       Date:  2020-11-10

4.  Early IL-2/sIL-2R surge following surgery leads to temporary immune refractoriness.

Authors:  N Lahat; R Shtiller; A Y Zlotnick; G Merin
Journal:  Clin Exp Immunol       Date:  1993-06       Impact factor: 4.330

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Journal:  J Trauma       Date:  2011-08

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Authors:  J B Ochoa; A C Bernard; W E O'Brien; M M Griffen; M E Maley; A K Rockich; B J Tsuei; B R Boulanger; P A Kearney; S M Morris
Journal:  Ann Surg       Date:  2001-03       Impact factor: 12.969

7.  Effects of interleukin-6 (IL-6) and transforming growth factor-beta (TGF-beta) on neutrophil elastase release.

Authors:  U Bank; D Reinhold; D Kunz; H U Schulz; C Schneemilch; W Brandt; S Ansorge
Journal:  Inflammation       Date:  1995-02       Impact factor: 4.092

8.  The release of transforming growth factor-beta following haemorrhage: its role as a mediator of host immunosuppression.

Authors:  A Ayala; D R Meldrum; M M Perrin; I H Chaudry
Journal:  Immunology       Date:  1993-07       Impact factor: 7.397

9.  Altered IL-10 levels in trauma patients' M phi and T lymphocytes.

Authors:  C L Miller-Graziano; A K De; K Kodys
Journal:  J Clin Immunol       Date:  1995-03       Impact factor: 8.317

10.  Autoregulation by eicosanoids of human Kupffer cell secretory products. A study of interleukin-1, interleukin-6, tumor necrosis factor-alpha, transforming growth factor-beta, and nitric oxide.

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Journal:  Ann Surg       Date:  1994-04       Impact factor: 12.969
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