J-b Yu1, S-l Yao. 1. Department of Anesthesiology, Tianjin Nankai Hospital, China. jianboyu99@yahoo.com.cn
Abstract
AIM: To investigate the effect of HO–CO on mortality during septic shock in rats. METHOD: Eighty rats were randomly divided into group-control, group ZnPP-IX, group SS, and group LZ. RESULTS: Death was significantly lower in group SS than in group LZ (P < 0.05). The MAP was significantly higher in the group LZ than in the group SS (P < 0.05). ALT, AST, Cr and BUN, MDA, and the lung EB contents, were significantly lower in the group SS than that in the group LZ (all P < 0.05). And CO and SOD activities were significantly higher in group SS than that in the group LZ (all P < 0.05). HO-1 mRNA, and HO-1 protein were significantly lower in the group LZ than in the group SS (P < 0.05), whereas HO-2 mRNA, and HO-2 protein were not significantly different among four groups (all P > 0.05). CONCLUSION: The increased oxidative stress and end-organ damage is related to mortality during septic shock; while the hypotension partly contributing to HO-1 protein and CO has no obvious relation with it.
AIM: To investigate the effect of HO–CO on mortality during septic shock in rats. METHOD: Eighty rats were randomly divided into group-control, group ZnPP-IX, group SS, and group LZ. RESULTS: Death was significantly lower in group SS than in group LZ (P < 0.05). The MAP was significantly higher in the group LZ than in the group SS (P < 0.05). ALT, AST, Cr and BUN, MDA, and the lung EB contents, were significantly lower in the group SS than that in the group LZ (all P < 0.05). And CO and SOD activities were significantly higher in group SS than that in the group LZ (all P < 0.05). HO-1 mRNA, and HO-1 protein were significantly lower in the group LZ than in the group SS (P < 0.05), whereas HO-2 mRNA, and HO-2 protein were not significantly different among four groups (all P > 0.05). CONCLUSION: The increased oxidative stress and end-organ damage is related to mortality during septic shock; while the hypotension partly contributing to HO-1 protein and CO has no obvious relation with it.
Authors: S F Yet; A Pellacani; C Patterson; L Tan; S C Folta; L Foster; W S Lee; C M Hsieh; M A Perrella Journal: J Biol Chem Date: 1997-02-14 Impact factor: 5.157
Authors: Diana Barrera; Perla D Maldonado; Omar N Medina-Campos; Rogelio Hernández-Pando; María E Ibarra-Rubio; José Pedraza-Chaverrí; José Pedraza-Chaverrrí Journal: Free Radic Biol Med Date: 2003-06-01 Impact factor: 7.376