Literature DB >> 1905272

Effects of indomethacin on prostaglandin E2 and thromboxane B2 contents of tracheal lavage fluids in premature infants.

J C Le Guennec1, M Lauzière, R Black, P Sirois.   

Abstract

A prospective longitudinal study was conducted in 14 premature infants intubated and receiving ventilatory support from birth, in order to evaluate the levels of prostaglandins E2 (PGE2) and thromboxane B2 (TxB2) in the tracheal lavage fluids (TLF) after treatment with indomethacin. Eight were treated with indomethacin, a cyclooxygenase inhibitor, for patient ductus arteriosus and the others served as controls. Infants who received indomethacin during the first postnatal week had significantly lower levels of eicosanoids in TLF during the first week. Our results suggest that levels of eicosanoids in TLF of premature infants are related to an inflammatory reaction and may serve as an index of the infant's overall clinical condition.

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Year:  1991        PMID： 1905272     DOI： 10.1007/bf00917909

Source DB:  PubMed          Journal:  Inflammation        ISSN： 0360-3997            Impact factor:   4.092


  11 in total

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Authors:  S P Hanley
Journal:  Lung       Date:  1986       Impact factor: 2.584

2.  Potential role of eicosanoids and PAF in the pathophysiology of bronchopulmonary dysplasia.

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Journal:  Am Rev Respir Dis       Date:  1987-09

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Authors:  J R Vane
Journal:  Nat New Biol       Date:  1971-06-23

4.  Enzyme immunoassays of eicosanoids using acetylcholine esterase as label: an alternative to radioimmunoassay.

Authors:  P Pradelles; J Grassi; J Maclouf
Journal:  Anal Chem       Date:  1985-06       Impact factor: 6.986

5.  Acute respiratory distress in adults.

Authors:  D G Ashbaugh; D B Bigelow; T L Petty; B E Levine
Journal:  Lancet       Date:  1967-08-12       Impact factor: 79.321

6.  Indomethacin and the preterm infant with a patent ductus arteriosus: relationship between plasma concentration and ductus closure.

Authors:  C A Friedman; B R Parks; J E Rawson; G A Serwer; P A Anderson
Journal:  Dev Pharmacol Ther       Date:  1982

7.  Release of prostaglandin E2 and thromboxane B2 by mixed isolated human lung cells.

Authors:  C Robidoux; J Maclouf; P Pradelles; P Sirois
Journal:  Prostaglandins Leukot Essent Fatty Acids       Date:  1988-04       Impact factor: 4.006

8.  Bronchopulmonary dysplasia: the pulmonary pathologic sequel of necrotizing bronchiolitis and pulmonary fibrosis.

Authors:  D S Bonikos; K G Bensch; W H NORTHWAY; D K Edwards
Journal:  Hum Pathol       Date:  1976-11       Impact factor: 3.466

9.  Pulmonary injury and prostaglandin production during endotoxemia in conscious sheep.

Authors:  R H Demling; M Smith; R Gunther; J T Flynn; M H Gee
Journal:  Am J Physiol       Date:  1981-03

10.  Role of intrapulmonary release of eicosanoids and superoxide anion as mediators of pulmonary dysfunction and endothelial injury in sheep with intermittent complement activation.

Authors:  S Z Perkowski; A M Havill; J T Flynn; M H Gee
Journal:  Circ Res       Date:  1983-11       Impact factor: 17.367
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