Literature DB >> 19052556

Toll-like receptors and cancer.

Seth Rakoff-Nahoum1, Ruslan Medzhitov.   

Abstract

Toll-like receptors (TLRs) are a family of pattern recognition receptors that are best-known for their role in host defence from infection. Emerging evidence also suggests that TLRs have an important role in maintaining tissue homeostasis by regulating the inflammatory and tissue repair responses to injury. The development of cancer has been associated with microbial infection, injury, inflammation and tissue repair. Here we discuss how the function of TLRs may relate to these processes in the context of carcinogenesis.

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Year:  2008        PMID： 19052556     DOI： 10.1038/nrc2541

Source DB:  PubMed          Journal:  Nat Rev Cancer        ISSN： 1474-175X            Impact factor:   60.716


  159 in total

1.  Toll-like receptors control activation of adaptive immune responses.

Authors:  M Schnare; G M Barton; A C Holt; K Takeda; S Akira; R Medzhitov
Journal:  Nat Immunol       Date:  2001-10       Impact factor: 25.606

Review 2.  Rapid leukocyte integrin activation by chemokines.

Authors:  Carlo Laudanna; Ji Yun Kim; Gabriela Constantin; Eugene Butcher
Journal:  Immunol Rev       Date:  2002-08       Impact factor: 12.988

3.  Polymorphisms in innate immunity genes and risk of non-Hodgkin lymphoma.

Authors:  Matthew S Forrest; Christine F Skibola; Tracy J Lightfoot; Paige M Bracci; Eleanor V Willett; Martyn T Smith; Elizabeth A Holly; Eve Roman
Journal:  Br J Haematol       Date:  2006-06-01       Impact factor: 6.998

Review 4.  Mammalian toll-like receptors: from endogenous ligands to tissue regeneration.

Authors:  Z Zhang; H J Schluesener
Journal:  Cell Mol Life Sci       Date:  2006-12       Impact factor: 9.261

5.  Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex.

Authors:  K Ohashi; V Burkart; S Flohé; H Kolb
Journal:  J Immunol       Date:  2000-01-15       Impact factor: 5.422

6.  Fibrinogen stimulates macrophage chemokine secretion through toll-like receptor 4.

Authors:  S T Smiley; J A King; W W Hancock
Journal:  J Immunol       Date:  2001-09-01       Impact factor: 5.422

7.  Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4.

Authors:  Alexzander Asea; Michael Rehli; Edith Kabingu; Jason A Boch; Olivia Bare; Philip E Auron; Mary Ann Stevenson; Stuart K Calderwood
Journal:  J Biol Chem       Date:  2002-02-08       Impact factor: 5.157

8.  MyD88-deficient mice develop severe intestinal inflammation in dextran sodium sulfate colitis.

Authors:  Akihiro Araki; Takanori Kanai; Takahiro Ishikura; Shin Makita; Koji Uraushihara; Ryoichi Iiyama; Teruji Totsuka; Kiyoshi Takeda; Shizuo Akira; Mamoru Watanabe
Journal:  J Gastroenterol       Date:  2005-01       Impact factor: 7.527

9.  The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells.

Authors:  Ryan T Phan; Riccardo Dalla-Favera
Journal:  Nature       Date:  2004-12-02       Impact factor: 49.962

10.  TLR4 enhances TGF-beta signaling and hepatic fibrosis.

Authors:  Ekihiro Seki; Samuele De Minicis; Christoph H Osterreicher; Johannes Kluwe; Yosuke Osawa; David A Brenner; Robert F Schwabe
Journal:  Nat Med       Date:  2007-10-21       Impact factor: 53.440
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  362 in total

1.  Are you my friends or are you my enemies?

Authors:  Amy H Tang
Journal:  Self Nonself       Date:  2011-07-01

2.  MTA1 coregulator regulates LPS response via MyD88-dependent signaling.

Authors:  Suresh B Pakala; Sirigiri Divijendra Natha Reddy; Tri M Bui-Nguyen; Siddharth S Rangparia; Anitha Bommana; Rakesh Kumar
Journal:  J Biol Chem       Date:  2010-08-11       Impact factor: 5.157

Review 3.  Immunity, inflammation, and cancer.

Authors:  Sergei I Grivennikov; Florian R Greten; Michael Karin
Journal:  Cell       Date:  2010-03-19       Impact factor: 41.582

4.  Toll-like receptor 3-mediated suppression of TRAMP prostate cancer shows the critical role of type I interferons in tumor immune surveillance.

Authors:  Arnold I Chin; Andrea K Miyahira; Anthony Covarrubias; Juli Teague; Beichu Guo; Paul W Dempsey; Genhong Cheng
Journal:  Cancer Res       Date:  2010-03-16       Impact factor: 12.701

5.  Contribution of MyD88 to the tumor exosome-mediated induction of myeloid derived suppressor cells.

Authors:  Yuelong Liu; Xiaoyu Xiang; Xiaoying Zhuang; Shuangyin Zhang; Cunren Liu; Ziqiang Cheng; Sue Michalek; William Grizzle; Huang-Ge Zhang
Journal:  Am J Pathol       Date:  2010-03-26       Impact factor: 4.307

Review 6.  Important aspects of Toll-like receptors, ligands and their signaling pathways.

Authors:  Z L Chang
Journal:  Inflamm Res       Date:  2010-07-01       Impact factor: 4.575

Review 7.  Mucins and toll-like receptors: kith and kin in infection and cancer.

Authors:  Shikha Tarang; Sushil Kumar; Surinder K Batra
Journal:  Cancer Lett       Date:  2012-02-03       Impact factor: 8.679

Review 8.  Structural insights into the assembly of large oligomeric signalosomes in the Toll-like receptor-interleukin-1 receptor superfamily.

Authors:  Ryan Ferrao; Jixi Li; Elisa Bergamin; Hao Wu
Journal:  Sci Signal       Date:  2012-05-29       Impact factor: 8.192

9.  Autophagy facilitates TLR4- and TLR3-triggered migration and invasion of lung cancer cells through the promotion of TRAF6 ubiquitination.

Authors:  Zhenzhen Zhan; Xuefeng Xie; Hao Cao; Xiaohui Zhou; Xu Dong Zhang; Huimin Fan; Zhongmin Liu
Journal:  Autophagy       Date:  2013-12-04       Impact factor: 16.016

Review 10.  Radiation and inflammation.

Authors:  Dörthe Schaue; Ewa D Micewicz; Josephine A Ratikan; Michael W Xie; Genhong Cheng; William H McBride
Journal:  Semin Radiat Oncol       Date:  2015-01       Impact factor: 5.934
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