OBJECTIVE: A seroconversion to mimivirus has been observed in patients with community-acquired or nosocomial pneumonia. The aim of this study was to determine whether a positive serology for mimivirus was associated with increased morbidity and mortality in patients with a suspicion of ventilator-associated pneumonia (VAP). DESIGN: Prospective matched-cohort study. SETTING: A 12-bed medical intensive care unit (ICU) in a teaching hospital. PATIENTS: Patients ventilated for at least 2 days presenting with a suspicion of VAP. Patients with a positive serology for mimivirus were matched to seronegative patients. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Matching criteria were: 1) the same main diagnosis on ICU admission, 2) the same age (+/- 10 yrs), 3) the same Simplified Acute Physiology II score (+/-10 points), 4) the same McCabe and Jackson comorbidity score, 5) admission within 1 year, and 6) diagnosis of at least one bacterial VAP during the ICU stay or not. A total of 55 pairs were submitted for analysis. The effectiveness of matching was 94.8%. Patients with a positive serology for mimivirus had longer duration of mechanical ventilation and ICU stay with median excesses of 7 days and 10 days, respectively. There was no difference in ICU mortality. The duration of mechanical ventilation before bronchoalveolar lavage (adjusted odds ratios [OR]1.08, p = 0.02), viral identification other than mimivirus during ICU stay (adjusted OR 0.32, p = 0.05), and enteral nutrition (adjusted OR 0.13, p = 0.01) were associated with positive serology for mimivirus. CONCLUSION: A positive serology for mimivirus is associated with a poorer outcome in mechanically ventilated ICU patients.
OBJECTIVE: A seroconversion to mimivirus has been observed in patients with community-acquired or nosocomial pneumonia. The aim of this study was to determine whether a positive serology for mimivirus was associated with increased morbidity and mortality in patients with a suspicion of ventilator-associated pneumonia (VAP). DESIGN: Prospective matched-cohort study. SETTING: A 12-bed medical intensive care unit (ICU) in a teaching hospital. PATIENTS: Patients ventilated for at least 2 days presenting with a suspicion of VAP. Patients with a positive serology for mimivirus were matched to seronegative patients. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Matching criteria were: 1) the same main diagnosis on ICU admission, 2) the same age (+/- 10 yrs), 3) the same Simplified Acute Physiology II score (+/-10 points), 4) the same McCabe and Jackson comorbidity score, 5) admission within 1 year, and 6) diagnosis of at least one bacterial VAP during the ICU stay or not. A total of 55 pairs were submitted for analysis. The effectiveness of matching was 94.8%. Patients with a positive serology for mimivirus had longer duration of mechanical ventilation and ICU stay with median excesses of 7 days and 10 days, respectively. There was no difference in ICU mortality. The duration of mechanical ventilation before bronchoalveolar lavage (adjusted odds ratios [OR]1.08, p = 0.02), viral identification other than mimivirus during ICU stay (adjusted OR 0.32, p = 0.05), and enteral nutrition (adjusted OR 0.13, p = 0.01) were associated with positive serology for mimivirus. CONCLUSION: A positive serology for mimivirus is associated with a poorer outcome in mechanically ventilated ICU patients.
Authors: Siyang Sun; Bernard La Scola; Valorie D Bowman; Christopher M Ryan; Julian P Whitelegge; Didier Raoult; Michael G Rossmann Journal: J Virol Date: 2009-11-04 Impact factor: 5.103
Authors: Sabri Bousbia; Laurent Papazian; Pierre Saux; Jean Marie Forel; Jean-Pierre Auffray; Claude Martin; Didier Raoult; Bernard La Scola Journal: PLoS One Date: 2012-02-28 Impact factor: 3.240
Authors: Sabri Bousbia; Laurent Papazian; Pierre Saux; Jean-Marie Forel; Jean-Pierre Auffray; Claude Martin; Didier Raoult; Bernard La Scola Journal: PLoS One Date: 2013-03-01 Impact factor: 3.240
Authors: Jônatas S Abrahão; Fábio P Dornas; Lorena C F Silva; Gabriel M Almeida; Paulo V M Boratto; Phillipe Colson; Bernard La Scola; Erna G Kroon Journal: Virol J Date: 2014-06-30 Impact factor: 4.099