Lynda A Nolan1, John M Nolan2, Frances S Shofer1, Nancy V Rodway3, Edward A Emmett4. 1. Center of Excellence in Environmental Toxicology, University of Pennsylvania School of Medicine, Philadelphia, PA, United States. 2. Department of Pediatrics, New York University School of Medicine, New York, NY, United States. 3. Division of Occupational Medicine, The Ohio State University College of Medicine, Columbus, OH, United States. 4. Center of Excellence in Environmental Toxicology, University of Pennsylvania School of Medicine, Philadelphia, PA, United States. Electronic address: emmetted@mail.med.upenn.edu.
Abstract
BACKGROUND: Recent studies have examined the associations between perfluorooctanoic acid (PFOA) levels in cord blood and maternal plasma with lowered birth weight and gestational age in humans; however, no study has examined these effects in a population of known high PFOA exposure. Residents drinking PFOA-contaminated water from the Little Hocking Water Association (LHWA) in Washington County, Ohio have serum PFOA levels approximately 80 times those in the general U.S. population. OBJECTIVES: To compare birth weights and gestational ages of neonates born to mothers residing in zip codes with water service provided completely, partially or not at all by the LHWA. METHODS: Multiple logistic and linear regression analyses were performed on singleton neonatal birth weight data supplied by the Ohio Department of Health to examine the associations between LHWA water service category (used as a surrogate for PFOA exposure) with mean birth weight, mean gestational age, the likelihood of low birth weight (<2500 g), and the likelihood of preterm birth (<37 completed weeks of gestation). All models were adjusted for maternal age, gestational age, sex, race and population-level socioeconomic status. RESULTS: The incidence of low birth weight, preterm birth, mean birth weight and mean gestational age of neonates did not significantly differ among water service categories. CONCLUSION: Markedly elevated PFOA exposure, as categorized by water service category, is not associated with increased risk of lowered birth weight or gestational age. This study does not confirm earlier findings of an association between PFOA and lowered birth weight observed at normal population levels.
BACKGROUND: Recent studies have examined the associations between perfluorooctanoic acid (PFOA) levels in cord blood and maternal plasma with lowered birth weight and gestational age in humans; however, no study has examined these effects in a population of known high PFOA exposure. Residents drinking PFOA-contaminated water from the Little Hocking Water Association (LHWA) in Washington County, Ohio have serum PFOA levels approximately 80 times those in the general U.S. population. OBJECTIVES: To compare birth weights and gestational ages of neonates born to mothers residing in zip codes with water service provided completely, partially or not at all by the LHWA. METHODS: Multiple logistic and linear regression analyses were performed on singleton neonatal birth weight data supplied by the Ohio Department of Health to examine the associations between LHWA water service category (used as a surrogate for PFOA exposure) with mean birth weight, mean gestational age, the likelihood of low birth weight (<2500 g), and the likelihood of preterm birth (<37 completed weeks of gestation). All models were adjusted for maternal age, gestational age, sex, race and population-level socioeconomic status. RESULTS: The incidence of low birth weight, preterm birth, mean birth weight and mean gestational age of neonates did not significantly differ among water service categories. CONCLUSION: Markedly elevated PFOA exposure, as categorized by water service category, is not associated with increased risk of lowered birth weight or gestational age. This study does not confirm earlier findings of an association between PFOA and lowered birth weight observed at normal population levels.
Authors: Barbara D Abbott; Cynthia J Wolf; Judith E Schmid; Kaberi P Das; Robert D Zehr; Laurence Helfant; Shoji Nakayama; Andrew B Lindstrom; Mark J Strynar; Christopher Lau Journal: Toxicol Sci Date: 2007-05-07 Impact factor: 4.849
Authors: Nobuyoshi Yamashita; Sachi Taniyasu; Gert Petrick; Si Wei; Toshitaka Gamo; Paul K S Lam; Kurunthachalam Kannan Journal: Chemosphere Date: 2007-09-12 Impact factor: 7.086
Authors: Shu-Ching Chang; Julie R Thibodeaux; Mary L Eastvold; David J Ehresman; James A Bjork; John W Froehlich; Christopher Lau; Ravinder J Singh; Kendall B Wallace; John L Butenhoff Journal: Toxicology Date: 2007-10-26 Impact factor: 4.221
Authors: Benjamin J Apelberg; Frank R Witter; Julie B Herbstman; Antonia M Calafat; Rolf U Halden; Larry L Needham; Lynn R Goldman Journal: Environ Health Perspect Date: 2007-11 Impact factor: 9.031
Authors: Antonia M Calafat; Lee-Yang Wong; Zsuzsanna Kuklenyik; John A Reidy; Larry L Needham Journal: Environ Health Perspect Date: 2007-11 Impact factor: 9.031
Authors: Amanda Ode; Lars Rylander; Christian H Lindh; Karin Källén; Bo A G Jönsson; Peik Gustafsson; Per Olofsson; Sten A Ivarsson; Anna Rignell-Hydbom Journal: Environ Sci Pollut Res Int Date: 2013-02-24 Impact factor: 4.223
Authors: Juliana Stone; Pragna Sutrave; Emily Gascoigne; Matthew B Givens; Rebecca C Fry; Tracy A Manuck Journal: Am J Obstet Gynecol MFM Date: 2021-01-11
Authors: Mitchell B Rosen; Judith R Schmid; J Christopher Corton; Robert D Zehr; Kaberi P Das; Barbara D Abbott; Christopher Lau Journal: PPAR Res Date: 2010-09-27 Impact factor: 4.964
Authors: Sharon K Sagiv; Sheryl L Rifas-Shiman; Abby F Fleisch; Thomas F Webster; Antonia M Calafat; Xiaoyun Ye; Matthew W Gillman; Emily Oken Journal: Am J Epidemiol Date: 2018-04-01 Impact factor: 4.897
Authors: Xiaoyun Ye; Kayoko Kato; Lee-Yang Wong; Tao Jia; Akil Kalathil; John Latremouille; Antonia M Calafat Journal: Int J Hyg Environ Health Date: 2017-09-29 Impact factor: 5.840