E Brodtkorb1, I J Bakken, O Sjaastad. 1. Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway. eylert.brodtkorb@ntnu.no
Abstract
BACKGROUND AND PURPOSE: Studies on the comorbidity of migraine and epilepsy have shown conflicting results. We wanted to explore the epidemiological association between migraine and seizure disorders in a population-based material where case ascertainment was enhanced by individual specialist assessments. METHODS: Information concerning migraine and seizure disorders was collected from 1793 participants in an interview-based survey in a circumscribed community. Mixed headache, with features both of migraine without aura and tension-type headache, was excluded from further analyses because of its ambiguous character (n = 137). Thus, data from 1656 participants were included in the study. RESULTS: The number of subjects with epilepsy was small, and a statistically significant association between migraine and the diagnosis of epilepsy was not found. There was a tendency to more active epilepsy in subjects with migraine (1.0%, 5/524), particularly for migraine with aura (1.8%, 3/168), compared with subjects without migraine (0.5%, 6/1132). Migraine was present in five of 11 subjects with active epilepsy (45%) and in four of 28 (14%) with epilepsy in remission (P = 0.09). CONCLUSIONS: An overall association between migraine and seizure disorders could not be demonstrated, but there was a tendency to more migraine in individuals with active epilepsy.
BACKGROUND AND PURPOSE: Studies on the comorbidity of migraine and epilepsy have shown conflicting results. We wanted to explore the epidemiological association between migraine and seizure disorders in a population-based material where case ascertainment was enhanced by individual specialist assessments. METHODS: Information concerning migraine and seizure disorders was collected from 1793 participants in an interview-based survey in a circumscribed community. Mixed headache, with features both of migraine without aura and tension-type headache, was excluded from further analyses because of its ambiguous character (n = 137). Thus, data from 1656 participants were included in the study. RESULTS: The number of subjects with epilepsy was small, and a statistically significant association between migraine and the diagnosis of epilepsy was not found. There was a tendency to more active epilepsy in subjects with migraine (1.0%, 5/524), particularly for migraine with aura (1.8%, 3/168), compared with subjects without migraine (0.5%, 6/1132). Migraine was present in five of 11 subjects with active epilepsy (45%) and in four of 28 (14%) with epilepsy in remission (P = 0.09). CONCLUSIONS: An overall association between migraine and seizure disorders could not be demonstrated, but there was a tendency to more migraine in individuals with active epilepsy.
Authors: Christoph J Schankin; Jan Rémi; Ira Klaus; Petra Sostak; Veronika M Reinisch; Soheyl Noachtar; Andreas Straube Journal: J Headache Pain Date: 2011-03-25 Impact factor: 7.277
Authors: G Mainieri; S Cevoli; G Giannini; L Zummo; C Leta; M Broli; L Ferri; M Santucci; A Posar; P Avoni; P Cortelli; P Tinuper; Francesca Bisulli Journal: J Headache Pain Date: 2015-08-06 Impact factor: 7.277