| Literature DB >> 19049472 |
Byungsook Kim1, Miseon Lee, Mi Jung Kim, Hyunjoo Lee, Sanghee Kim, Deukjoon Kim, Minseob Koh, Seung Bum Park, Kye Jung Shin.
Abstract
The first asymmetric total synthesis of (-)-laurefucin (1), a unique C-15 acetogenin with a 2,8-dioxabicyclo[5.2.1]decane skeleton, has been accomplished in nine steps in 31% overall yield from known oxocene 10. Highlights of the highly stereoselective synthesis include a novel organoselenium-mediated biomimetic hydroxyetherification.Entities:
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Year: 2008 PMID： 19049472 DOI： 10.1021/ja806304s
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419