Literature DB >> 19048884

[Influence of amino acids alimentary on contracts ability in 13-adreno- and M-cholinoreactivity of smooth muscles].

E N Sizova, V I Tsirkin, T V Tumanova.   

Abstract

It was studied the influence of 20 amino acids on beta-adreno- and M-cholinoreactivity of longitudinal strips (n = 268) of rat uterus horn (n = 46) with the help of adrenaline (10(-8) g/ml) and acetilcholine (10(-6) g/Ml) accordingly. It is shown, that 3 amino acids from 20, including L-histidine (3 x 10(-8) - 3 x 10(-5) g/ml), L-triptophan (10(-8) - 10(-5)) and D-, L-tyrosine (2 x 10(-8) - 2 x 10(-5)), not changing M-cholinoreactivity of uterus smooth muscles, everyone or complexly essentially raised their beta-adrenoreactivity, i.e. expressed their beta-adrenosensibilisatory activity. It allows to consider that this amino acids are possible components of endogenic sensibilisator of beta-adrenocepters. It is discussed the question about using this amino acids in a dietary meal and complex therapy at insufficiency of beta-adrenergic influences on visceral organs.

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Year:  2008        PMID: 19048884

Source DB:  PubMed          Journal:  Vopr Pitan        ISSN: 0042-8833


  1 in total

1.  An endogenous sensitizer of β-adrenergic receptors and its analogs in the experiments with rat myometrium reduce the β-adrenoblocking effect of obzidan.

Authors:  V I Tsirkin; A D Nozdrachev; A L Toropov
Journal:  Dokl Biol Sci       Date:  2011-01-09
  1 in total

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