Literature DB >> 19048166

Evaluation of aspirin metabolites as inhibitors of hypoxia-inducible factor hydroxylases.

Benoit M Lienard1, Ana Conejo-García, Ineke Stolze, Christoph Loenarz, Neil J Oldham, Peter J Ratcliffe, Christopher J Schofield.   

Abstract

Known and potential aspirin metabolites were evaluated as inhibitors of oxygen-sensing hypoxia-inducible transcription factor (HIF) hydroxylases; some of the metabolites were found to stabilise HIF-alpha in cells.

Entities:  

Mesh：

Substances：

Year:  2008        PMID： 19048166     DOI： 10.1039/b814440k

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  4 in total

1.  Preconditioning of Cardiosphere-Derived Cells With Hypoxia or Prolyl-4-Hydroxylase Inhibitors Increases Stemness and Decreases Reliance on Oxidative Metabolism.

Authors:  Suat Cheng Tan; Renata S M Gomes; Kar Kheng Yeoh; Filippo Perbellini; Sophia Malandraki-Miller; Lucy Ambrose; Lisa C Heather; Giuseppe Faggian; Christopher J Schofield; Kay E Davies; Kieran Clarke; Carolyn A Carr
Journal:  Cell Transplant       Date:  2015-03-06       Impact factor: 4.064

2.  Identification of valid housekeeping genes for quantitative RT-PCR analysis of cardiosphere-derived cells preconditioned under hypoxia or with prolyl-4-hydroxylase inhibitors.

Authors:  Suat Cheng Tan; Carolyn A Carr; Kar Kheng Yeoh; Christopher J Schofield; Kay E Davies; Kieran Clarke
Journal:  Mol Biol Rep       Date:  2011-11-09       Impact factor: 2.316

3.  Effect of proline analogues on activity of human prolyl hydroxylase and the regulation of HIF signal transduction pathway.

Authors:  Xiaoyan Ma; Xiaoxin Wang; Jing Cao; Zhirong Geng; Zhilin Wang
Journal:  PLoS One       Date:  2014-04-22       Impact factor: 3.240

4.  Dual-action inhibitors of HIF prolyl hydroxylases that induce binding of a second iron ion.

Authors:  Kar Kheng Yeoh; Mun Chiang Chan; Armin Thalhammer; Marina Demetriades; Rasheduzzaman Chowdhury; Ya-Min Tian; Ineke Stolze; Luke A McNeill; Myung Kyu Lee; Esther C Y Woon; Mukram M Mackeen; Akane Kawamura; Peter J Ratcliffe; Jasmin Mecinović; Christopher J Schofield
Journal:  Org Biomol Chem       Date:  2012-11-15       Impact factor: 3.876
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.