Literature DB >> 19048144

Secure route to the epoxybicyclo[7.3.0]dodecadienediyne core of the kedarcidin chromophore.

Kouki Ogawa1, Yasuhito Koyama, Isao Ohashi, Itaru Sato, Masahiro Hirama.   

Abstract

Formation of an epoxide before 9-membered ring cyclization and SmI2 mediated reductive olefination in the presence of the epoxide successfully produced the epoxybicyclo[7.3.0]dodecadienediyne core of the kedarcidin chromophore.

Entities:  

Year:  2008        PMID: 19048144     DOI: 10.1039/b814595d

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN: 1359-7345            Impact factor:   6.222


  2 in total

1.  9-Membered carbocycle formation: development of distinct Friedel-Crafts cyclizations and application to a scalable total synthesis of (±)-caraphenol A.

Authors:  Nathan E Wright; Scott A Snyder
Journal:  Angew Chem Int Ed Engl       Date:  2014-03-24       Impact factor: 15.336

Review 2.  Total synthesis and related studies of large, strained, and bioactive natural products.

Authors:  Masahiro Hirama
Journal:  Proc Jpn Acad Ser B Phys Biol Sci       Date:  2016       Impact factor: 3.493

  2 in total

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