BACKGROUND: This study was designed to clarify the relationship between myocardial damage and platelet-neutrophil aggregation in patients with acute myocardial infarction (AMI). METHODS AND RESULTS: The study group comprised 107 patients with ST-segment elevation AMI, in whom aspiration catheter was used during emergency percutaneous coronary intervention. Patients were divided into 2 groups according to the cellular density of neutrophils in the aspirated sample: group L (n=53), <or=100 neutrophils/0.025 mm(2) thrombus; group H (n=54), >100 neutrophils/0.025 mm(2) thrombus. Myocardial blush grade (MBG) <or=1 and ST-segment resolution (STR) <50% were more frequently found in group H than in group L. Peak creatine kinase level tended to be higher and left ventricular ejection fraction (LVEF) at 6 months after onset was lower in group H than in group L. Multivariate analysis showed that high neutrophil density in aspirated thrombus was an independent predictor of MBG <or=1, STR <50%, and low LVEF at 6 months after onset. CONCLUSIONS: Platelet-neutrophil aggregates retrieved from ruptured plaque may be associated with impaired coronary microcirculation and resultant myocardial necrosis/dysfunction. These findings underscore the clinical importance of the interaction between thrombosis and inflammation in the pathogenesis of AMI.
BACKGROUND: This study was designed to clarify the relationship between myocardial damage and platelet-neutrophil aggregation in patients with acute myocardial infarction (AMI). METHODS AND RESULTS: The study group comprised 107 patients with ST-segment elevation AMI, in whom aspiration catheter was used during emergency percutaneous coronary intervention. Patients were divided into 2 groups according to the cellular density of neutrophils in the aspirated sample: group L (n=53), <or=100 neutrophils/0.025 mm(2) thrombus; group H (n=54), >100 neutrophils/0.025 mm(2) thrombus. Myocardial blush grade (MBG) <or=1 and ST-segment resolution (STR) <50% were more frequently found in group H than in group L. Peak creatine kinase level tended to be higher and left ventricular ejection fraction (LVEF) at 6 months after onset was lower in group H than in group L. Multivariate analysis showed that high neutrophil density in aspirated thrombus was an independent predictor of MBG <or=1, STR <50%, and low LVEF at 6 months after onset. CONCLUSIONS: Platelet-neutrophil aggregates retrieved from ruptured plaque may be associated with impaired coronary microcirculation and resultant myocardial necrosis/dysfunction. These findings underscore the clinical importance of the interaction between thrombosis and inflammation in the pathogenesis of AMI.
Authors: Mehran Ghasemzadeh; Zane S Kaplan; Imala Alwis; Simone M Schoenwaelder; Katrina J Ashworth; Erik Westein; Ehteramolsadat Hosseini; Hatem H Salem; Robyn Slattery; Shaun R McColl; Michael J Hickey; Zaverio M Ruggeri; Yuping Yuan; Shaun P Jackson Journal: Blood Date: 2013-04-02 Impact factor: 22.113
Authors: Hye Young Lee; Jeong Hoon Kim; Byung Ok Kim; Yoon Jung Kang; Hyo Seung Ahn; Mee Won Hwang; Kyoung Min Park; Young Sup Byun; Choong Won Goh; Kun Joo Rhee Journal: Korean Circ J Date: 2011-02-28 Impact factor: 3.243