Literature DB >> 1904752

Pharmacological activity of the dinitrate metabolites of nitroglycerin following their oral administration to healthy volunteers.

M Gumbleton, L Z Benet.   

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Year:  1991        PMID： 1904752      PMCID： PMC1368399          DOI： 10.1111/j.1365-2125.1991.tb05521.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


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  6 in total

1.  The bioavailability of oral nitroglycerin.

Authors:  P K Noonan; L Z Benet
Journal:  J Pharm Sci       Date:  1986-03       Impact factor: 3.534

2.  Pharmacokinetics of nitroglycerin and its dinitrate metabolites over a thirtyfold range of oral doses.

Authors:  E Nakashima; J F Rigod; E T Lin; L Z Benet
Journal:  Clin Pharmacol Ther       Date:  1990-05       Impact factor: 6.875

3.  Effect of sustained release nitroglycerin capsules on anginal frequency and exercise capacity: a double-blind evaluation.

Authors:  M E Davidov; W J Mroczek
Journal:  Angiology       Date:  1977-03       Impact factor: 3.619

4.  Variable glyceryl dinitrate formation as a function of route of nitroglycerin administration.

Authors:  P K Noonan; L Z Benet
Journal:  Clin Pharmacol Ther       Date:  1987-09       Impact factor: 6.875

5.  Oral nitroglycerin as a prophylactic antianginal drug: clinical, physiologic, and statistical evidence of efficacy based on a three-phase experimental design.

Authors:  T Winsor; H J Berger
Journal:  Am Heart J       Date:  1975-11       Impact factor: 4.749

6.  Pharmacokinetics of nitroglycerin and metabolites in humans following oral dosing.

Authors:  D K Yu; R L Williams; L Z Benet; E T Lin; D H Giesing
Journal:  Biopharm Drug Dispos       Date:  1988 Nov-Dec       Impact factor: 1.627
  6 in total
  11 in total

1.  Heating and cooling of the nitroglycerin patch application area modify the plasma level of nitroglycerin.

Authors:  T O Klemsdal; K Gjesdal; J E Bredesen
Journal:  Eur J Clin Pharmacol       Date:  1992       Impact factor: 2.953

Review 2.  Mechanisms of action of nitrates.

Authors:  K E Torfgård; J Ahlner
Journal:  Cardiovasc Drugs Ther       Date:  1994-10       Impact factor: 3.727

3.  Vascular and anti-platelet actions of 1,2- and 1,3-glyceryl dinitrate.

Authors:  D Salvemini; A Pistelli; E Anggard
Journal:  Br J Pharmacol       Date:  1993-11       Impact factor: 8.739

Review 4.  Organic nitrate metabolism and action: toward a unifying hypothesis and the future-a dedication to Professor Leslie Z. Benet.

Authors:  Nathaniel A Page; Ho-Leung Fung
Journal:  J Pharm Sci       Date:  2013-05-13       Impact factor: 3.534

5.  Percutaneous penetration kinetics of nitroglycerin and its dinitrate metabolites across hairless mouse skin in vitro.

Authors:  T Kikkoji; M Gumbleton; N Higo; R H Guy; L Z Benet
Journal:  Pharm Res       Date:  1991-10       Impact factor: 4.200

6.  Simultaneous pharmacodynamic modeling of the non-steady-state effects of three oral doses of 1,3-glyceryl dinitrate upon blood pressure in healthy volunteers.

Authors:  M Gumbleton; L Z Benet
Journal:  J Pharmacokinet Biopharm       Date:  1993-10

7.  Pharmacodynamic models of nitroglycerin-induced hemodynamic tolerance in experimental heart failure.

Authors:  J A Bauer; H L Fung
Journal:  Pharm Res       Date:  1994-06       Impact factor: 4.200

8.  Clinical pharmacological equivalence of a novel FCH-free GTN spray with low ethanol content vs a FCH-containing GTN spray.

Authors:  C de Mey; K Erb; T Zimmermann; H Mutschler; H Blume; G G Belz
Journal:  Eur J Clin Pharmacol       Date:  1995       Impact factor: 2.953

9.  Pharmacokinetics and pharmacodynamics of nitroglycerin and its dinitrate metabolites in conscious dogs: intravenous infusion studies.

Authors:  F W Lee; T Salmonson; L Z Benet
Journal:  J Pharmacokinet Biopharm       Date:  1993-10

10.  Dose proportionality of transdermal nitroglycerin.

Authors:  R C Jewell; C R Banfield; D A Ruggirello; Y W Huang; P K Noonan; M A Gonzalez
Journal:  Pharm Res       Date:  1992-10       Impact factor: 4.200
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