| Literature DB >> 19047013 |
R Spoelgen1, K W Adams, M Koker, A V Thomas, O M Andersen, P J Hallett, K K Bercury, D F Joyner, M Deng, W H Stoothoff, D K Strickland, T E Willnow, B T Hyman.
Abstract
In this study, we examined protein-protein interactions between two neuronal receptors, low density lipoprotein receptor-related protein (LRP) and sorLA/LR11, and found that these receptors interact, as indicated by three independent lines of evidence: co-immunoprecipitation experiments on mouse brain extracts and mouse neuronal cells, surface plasmon resonance analysis with purified human LRP and sorLA, and fluorescence lifetime imaging microscopy (FLIM) on rat primary cortical neurons. Immunocytochemistry experiments revealed widespread co-localization of LRP and sorLA within perinuclear compartments of rat primary neurons, while FLIM analysis showed that LRP-sorLA interactions take place within a subset of these compartments.Entities:
Mesh：
Substances：
Year: 2008 PMID： 19047013 PMCID： PMC2709796 DOI： 10.1016/j.neuroscience.2008.10.061
Source DB: PubMed Journal: Neuroscience ISSN： 0306-4522 Impact factor: 3.590