BACKGROUND: There is a lack of information on long term complications of patients with pulmonary embolism (PE), including chronic complaints of dyspnea. METHODS: Consecutive patients with a prior diagnosis of acute PE and an age and gender matched control group with no medical history of PE were presented with a questionnaire, designed to establish the presence, severity and possible causes of dyspnea in the clinical course of PE. RESULTS: The questionnaire was taken in 48 PE-survivors 40+/-7.4 months after PE; 27 patients (56%) had complaints of dyspnea. Sixteen (35%) were categorized as NYHA class II, 6 (13%) as class III and 5 (10%) as class IV. Overall, 19 patients (70%) had new or worsened complaints after PE. The study included 61 controls. Corrected for gender, age and medical history, the control group was significantly less dyspnoeic compared to the PE survivors (p<0.001). Corrected for gender and age, patients were 4 times more often in NYHA class II (OR 3.6 95%CI 1.4-9.7) and 7-fold more often in NYHA class III or IV (OR 6.5 95%CI 1.7-24), both compared to control subjects. CONCLUSION: A large percentage of patients with prior PE have persistent complaints of dyspnea at long term follow-up. The majority of them developed new or worsened dyspnea after the thrombo-embolic event. In comparison to a control population without a medical history of VTE, PE patients were overall significantly more dyspnoeic. An explanation for this phenomenon needs to be studied in further functional work-up of these patients.
BACKGROUND: There is a lack of information on long term complications of patients with pulmonary embolism (PE), including chronic complaints of dyspnea. METHODS: Consecutive patients with a prior diagnosis of acute PE and an age and gender matched control group with no medical history of PE were presented with a questionnaire, designed to establish the presence, severity and possible causes of dyspnea in the clinical course of PE. RESULTS: The questionnaire was taken in 48 PE-survivors 40+/-7.4 months after PE; 27 patients (56%) had complaints of dyspnea. Sixteen (35%) were categorized as NYHA class II, 6 (13%) as class III and 5 (10%) as class IV. Overall, 19 patients (70%) had new or worsened complaints after PE. The study included 61 controls. Corrected for gender, age and medical history, the control group was significantly less dyspnoeic compared to the PE survivors (p<0.001). Corrected for gender and age, patients were 4 times more often in NYHA class II (OR 3.6 95%CI 1.4-9.7) and 7-fold more often in NYHA class III or IV (OR 6.5 95%CI 1.7-24), both compared to control subjects. CONCLUSION: A large percentage of patients with prior PE have persistent complaints of dyspnea at long term follow-up. The majority of them developed new or worsened dyspnea after the thrombo-embolic event. In comparison to a control population without a medical history of VTE, PE patients were overall significantly more dyspnoeic. An explanation for this phenomenon needs to be studied in further functional work-up of these patients.
Authors: Mazdak Tavoly; Lars-Petter Jelsness-Jørgensen; Hilde Skuterud Wik; Christina Roaldsnes; Per Morten Sandset; Waleed Ghanima Journal: Qual Life Res Date: 2014-08-14 Impact factor: 4.147
Authors: Bedros Taslakian; Clayton Li; Samuel Z Goldhaber; Kathryn Z Mikkelsen; James M Horowitz; Christopher Kabrhel; Geoffrey D Barnes; Akhilesh K Sista Journal: J Clin Med Date: 2019-02-07 Impact factor: 4.241
Authors: Ling-Hsiang Chuang; Pearl Gumbs; Ben van Hout; Giancarlo Agnelli; Sonja Kroep; Manuel Monreal; Rupert Bauersachs; Stephen N Willich; Anselm Gitt; Patrick Mismetti; Alexander Cohen; David Jimenez Journal: Qual Life Res Date: 2019-04-04 Impact factor: 4.147
Authors: Roisin Bavalia; Ingrid M Bistervels; Wim G Boersma; Isabelle Quere; Dominique Brisot; Nicolas Falvo; Dominique Stephan; Francis Couturaud; Sebastian Schellong; Jan Beyer-Westendorf; Karine Montaclair; Waleed Ghanima; Marije Ten Wolde; Michiel Coppens; Emile Ferrari; Olivier Sanchez; Patrick Carroll; Pierre-Marie Roy; Susan R Kahn; Karina Meijer; Simone Birocchi; Michael J Kovacs; Amanda Hugman; Hugo Ten Cate; Hilde Wik; Gilles Pernod; Marie-Antoinette Sevestre-Pietri; Michael A Grosso; Minggao Shi; Yong Lin; Barbara A Hutten; Peter Verhamme; Saskia Middeldorp Journal: Res Pract Thromb Haemost Date: 2021-07-14