Literature DB >> 1904371

Isolation of a novel arachidonic acid metabolite 3-hydroxy-5,8,11,14-eicosatetraenoic acid (3-HETE) from the yeast Dipodascopsis uninucleata UOFs-Y128.

M S van Dyk1, J L Kock, D J Coetzee, O P Augustyn, S Nigam.   

Abstract

When arachidonic acid (AA) is added to the yeast Dipodascopsis uninucleata UOFS Y128, one of the major metabolites isolated and purified with the help of thin layer chromatography (TLC) and high performance liquid chromatography (HPLC) is 3-hydroxy-5,8,11,14-eicosatetraenoic acid (3-HETE). The structure of this new AA metabolite was elucidated mainly by electron impact (EI) mass spectrometry (MS). Strikingly, the formation of this new metabolite was found to be inhibited by aspirin.

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Year:  1991        PMID： 1904371     DOI： 10.1016/0014-5793(91)80586-r

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  13 in total

Review 1.  Production of cross-kingdom oxylipins by pathogenic fungi: An update on their role in development and pathogenicity.

Authors:  Gregory J Fischer; Nancy P Keller
Journal:  J Microbiol       Date:  2016-02-27       Impact factor: 3.422

2.  Oxygenation by COX-2 (cyclo-oxygenase-2) of 3-HETE (3-hydroxyeicosatetraenoic acid), a fungal mimetic of arachidonic acid, produces a cascade of novel bioactive 3-hydroxyeicosanoids.

Authors:  Roberto Ciccoli; Shakti Sahi; Sandhya Singh; Hridayesh Prakash; Maria-Patapia Zafiriou; Ganchimeg Ishdorj; Johan L F Kock; Santosh Nigam
Journal:  Biochem J       Date:  2005-09-15       Impact factor: 3.857

3.  Evidence for the mitochondrial biosynthesis of 3R-hydroxy-5Z,8Z,11Z,1 4Z-eicosatetraenoic acid in the yeast Dipodascopsis uninucleata.

Authors:  S R Fox; M Hamberg; J Friend; C Ratledge
Journal:  Lipids       Date:  2000-11       Impact factor: 1.880

4.  Bacterial metabolism of human polymorphonuclear leukocyte-derived arachidonic acid.

Authors:  T C Sorrell; M Muller; K Sztelma
Journal:  Infect Immun       Date:  1992-05       Impact factor: 3.441

5.  Production of 3R-hydroxy-polyenoic fatty acids by the yeast Dipodascopsis uninucleata.

Authors:  P Venter; J L Kock; G S Kumar; A Botha; D J Coetzee; P J Botes; R K Bhatt; J R Falck; T Schewe; S Nigam
Journal:  Lipids       Date:  1997-12       Impact factor: 1.880

Review 6.  Production of eicosanoids and other oxylipins by pathogenic eukaryotic microbes.

Authors:  Mairi C Noverr; John R Erb-Downward; Gary B Huffnagle
Journal:  Clin Microbiol Rev       Date:  2003-07       Impact factor: 26.132

7.  Hydroxy long-chain fatty acids in fungi.

Authors:  M S Van Dyk; J L Kock; A Botha
Journal:  World J Microbiol Biotechnol       Date:  1994-09       Impact factor: 3.312

8.  Effect of salt stress on fatty acid alterations in some strains of Dipodascopsis and Dipodascus spp.

Authors:  J Sajbidor; M Lamačka; E Breirerová; A Chrastina; P Pokreisz; M Certík
Journal:  World J Microbiol Biotechnol       Date:  1994-03       Impact factor: 3.312

9.  The distribution and taxonomic value of fatty acids and eicosanoids in the Lipomycetaceae and Dipodascaceae.

Authors:  A Botha; J L Kock
Journal:  Antonie Van Leeuwenhoek       Date:  1993-02       Impact factor: 2.271

10.  Chemical synthesis, pharmacological characterization, and possible formation in unicellular fungi of 3-hydroxy-anandamide.

Authors:  L De Petrocellis; R Deva; F Mainieri; M Schaefer; T Bisogno; R Ciccoli; A Ligresti; K Hill; S Nigam; G Appendino; V Di Marzo
Journal:  J Lipid Res       Date:  2008-11-17       Impact factor: 5.922
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