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Literature DB >> 19043246

Flavonoids from the heartwood of Dalbergia odorifera and their protective effect on glutamate-induced oxidative injury in HT22 cells.

Ren-Bo An¹, Gil-Saeng Jeong, Youn-Chul Kim.

Abstract

Two flavonoids, 4,2',5'-trihydroxy-4'-methoxychalcone (1) and (2S)-6,7,4'-trihydroxyflavan (2), along with fourteen known flavonoids and two other known arylbenzofurans were isolated from the heartwood of Dalbergia odorifera. The structure of compounds 1 and 2 were established by spectroscopic (NMR and MS) analyses. Of the isolates, eight compounds (1, 4, 7, 10, 12, 14, 15, 17) were found to have potent protective effect on glutamate-induced oxidative injury in HT22 cells.

Entities: Chemical Disease Species

Mesh：

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Year: 2008 PMID： 19043246 DOI： 10.1248/cpb.56.1722

Source DB: PubMed Journal: Chem Pharm Bull (Tokyo) ISSN： 0009-2363 Impact factor: 1.645

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Cited

10 in total

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Authors: Erick Korir; Joyce J Kiplimo; Neil R Crouch; Nivan Moodley; Neil A Koorbanally
Journal: Afr J Tradit Complement Altern Med Date: 2014-08-23

2. Heme Oxygenase-1-Inducing Activity of 4-Methoxydalbergione and 4'-Hydroxy-4-methoxydalbergione from Dalbergia odorifera and Their Anti-inflammatory and Cytoprotective Effects in Murine Hippocampal and BV2 Microglial Cell Line and Primary Rat Microglial Cells.

Authors: Dong-Cheol Kim; Dong-Sung Lee; Wonmin Ko; Kwan-Woo Kim; Hye Jin Kim; Chi-Su Yoon; Hyuncheol Oh; Youn-Chul Kim
Journal: Neurotox Res Date: 2017-08-23 Impact factor: 3.911

3. 2,4,5-Trimethoxyldalbergiquinol promotes osteoblastic differentiation and mineralization via the BMP and Wnt/β-catenin pathway.

Authors: H-M Yun; K-R Park; T H Quang; H Oh; J T Hong; Y-C Kim; E-C Kim
Journal: Cell Death Dis Date: 2015-07-16 Impact factor: 8.469

4. Diverse fungi associated with partial irregular heartwood of Dalbergia odorifera.

Authors: Sisheng Sun; Xu Zeng; Dawei Zhang; Shunxing Guo
Journal: Sci Rep Date: 2015-02-16 Impact factor: 4.379

5. 4-Methoxydalbergione suppresses growth and induces apoptosis in human osteosarcoma cells in vitro and in vivo xenograft model through down-regulation of the JAK2/STAT3 pathway.

Authors: Kyung-Ran Park; Hyung-Mun Yun; Tran-Hong Quang; Hyuncheol Oh; Dong-Sung Lee; Q-Schick Auh; Eun-Cheol Kim
Journal: Oncotarget Date: 2016-02-09

Flavonoids from the heartwood of Dalbergia odorifera and their protective effect on glutamate-induced oxidative injury in HT22 cells.

1. Isoflavones from Calpurnia Aurea subsp. aurea and their anticancer activity.

2. Heme Oxygenase-1-Inducing Activity of 4-Methoxydalbergione and 4'-Hydroxy-4-methoxydalbergione from Dalbergia odorifera and Their Anti-inflammatory and Cytoprotective Effects in Murine Hippocampal and BV2 Microglial Cell Line and Primary Rat Microglial Cells.

3. 2,4,5-Trimethoxyldalbergiquinol promotes osteoblastic differentiation and mineralization via the BMP and Wnt/β-catenin pathway.

4. Diverse fungi associated with partial irregular heartwood of Dalbergia odorifera.

5. 4-Methoxydalbergione suppresses growth and induces apoptosis in human osteosarcoma cells in vitro and in vivo xenograft model through down-regulation of the JAK2/STAT3 pathway.

6. Antibacterial activity of the flavonoids from Dalbergia odorifera on Ralstonia solanacearum.

7. Cearoin Induces Autophagy, ERK Activation and Apoptosis via ROS Generation in SH-SY5Y Neuroblastoma Cells.

8. DRG2 Accelerates Senescence via Negative Regulation of SIRT1 in Human Diploid Fibroblasts.

Review 9. A Review on the Medicinal Plant Dalbergia odorifera Species: Phytochemistry and Biological Activity.

Review 10. Recent progress on the traditional Chinese medicines that regulate the blood.