Literature DB >> 19043240

Hydronaphthalenones and a dihydroramulosin from the endophytic fungus PSU-N24.

Ubonta Sommart1, Vatcharin Rukachaisirikul, Yaowapa Sukpondma, Souwalak Phongpaichit, Jariya Sakayaroj, Kanyawim Kirtikara.   

Abstract

Three new hydronaphthalenone derivatives (1-3) and one new dihydroramulosin derivative (4), were isolated from the endophytic fungus PSU-N24 together with eight known compounds. Their structures were elucidated by spectroscopic methods. Griseofulvin (9) displayed strong antifungal activity against Microsporum gypseum SH-MU-4 with a minimum inhibitory concentration (MIC) value of 2 microg/ml while all metabolites exhibited very weak antibacterial activity (MIC value>or=128 microg/ml) against Staphylococcus aureus, both standard and methicillin-resistant strains. 3-(2-Hydroxypropyl)benzene-1,2-diol (10) showed moderate antimalarial activity against Plasmodiun falciparum with an IC(50) value of 6.68 microg/ml. For antimycobacterial activity against Mycobacterium tuberculosis, compound 3 gave the best activity with the MIC value of 12.50 microg/ml.

Entities:  

Mesh：

Substances：

Year:  2008        PMID： 19043240     DOI： 10.1248/cpb.56.1687

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN： 0009-2363            Impact factor:   1.645


  7 in total

Review 1.  Naturally Occurring Isocoumarins Derivatives from Endophytic Fungi: Sources, Isolation, Structural Characterization, Biosynthesis, and Biological Activities.

Authors:  Ahmad Omar Noor; Diena Mohammedallam Almasri; Alaa Abdullah Bagalagel; Hossam Mohamed Abdallah; Shaimaa Gamal Abdallah Mohamed; Gamal Abdallah Mohamed; Sabrin Ragab Mohamed Ibrahim
Journal:  Molecules       Date:  2020-01-17       Impact factor: 4.411

2.  Alterporriol-type dimers from the mangrove endophytic fungus, Alternaria sp. (SK11), and their MptpB inhibitions.

Authors:  Guoping Xia; Jia Li; Hanxiang Li; Yuhua Long; Shao'e Lin; Yongjun Lu; Lei He; Yongcheng Lin; Lan Liu; Zhigang She
Journal:  Mar Drugs       Date:  2014-05-16       Impact factor: 5.118

Review 3.  Endophytic fungi: a reservoir of antibacterials.

Authors:  Sunil K Deshmukh; Shilpa A Verekar; Sarita V Bhave
Journal:  Front Microbiol       Date:  2015-01-08       Impact factor: 5.640

4.  Anti-mycobacterial activity of marine fungus-derived 4-deoxybostrycin and nigrosporin.

Authors:  Cong Wang; Juan Wang; Yuhong Huang; Hong Chen; Yan Li; Lili Zhong; Yi Chen; Shengping Chen; Jun Wang; Juling Kang; Yi Peng; Bin Yang; Yongcheng Lin; Zhigang She; Xiaomin Lai
Journal:  Molecules       Date:  2013-01-29       Impact factor: 4.411

Review 5.  Fungal Naphthalenones; Promising Metabolites for Drug Discovery: Structures, Biosynthesis, Sources, and Pharmacological Potential.

Authors:  Sabrin R M Ibrahim; Sana A Fadil; Haifa A Fadil; Bayan A Eshmawi; Shaimaa G A Mohamed; Gamal A Mohamed
Journal:  Toxins (Basel)       Date:  2022-02-19       Impact factor: 4.546

Review 6.  Chemical diversity, medicinal potentialities, biosynthesis, and pharmacokinetics of anthraquinones and their congeners derived from marine fungi: a comprehensive update.

Authors:  Mohamed Sebak; Fatma Molham; Claudio Greco; Mohamed A Tammam; Mansour Sobeh; Amr El-Demerdash
Journal:  RSC Adv       Date:  2022-09-01       Impact factor: 4.036

7.  Synthesis and antitumor activities of derivatives of the marine mangrove fungal metabolite deoxybostrycin.

Authors:  Hong Chen; Xun Zhu; Li-Li Zhong; Bing Yang; Jia Li; Jue-Heng Wu; Sheng-Ping Chen; Yong-Cheng Lin; Yuhua Long; Zhi-Gang She
Journal:  Mar Drugs       Date:  2012-11-30       Impact factor: 5.118
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.