Literature DB >> 19042033

S100B secretion is stimulated by IL-1beta in glial cultures and hippocampal slices of rats: Likely involvement of MAPK pathway.

Daniela F de Souza1, Marina C Leite, André Quincozes-Santos, Patrícia Nardin, Lucas S Tortorelli, Maurício M Rigo, Carmem Gottfried, Rodrigo B Leal, Carlos-Alberto Gonçalves.   

Abstract

S100B is an astrocyte-derived cytokine implicated in the IL-1beta-triggered cytokine cycle in Alzheimer's disease. However, the secretion of S100B following stimulation by IL-1beta has not been directly demonstrated. We investigated S100B secretion in cortical primary astrocyte cultures, C6 glioma cells and acute hippocampal slices exposed to IL-1beta. S100B secretion was induced by IL-1beta in all preparations, involving MAPK pathway and, apparently, NF-small ka, CyrillicB signaling. Astrocytes and C6 cells exhibited different sensitivities to IL-1beta. These results suggest that IL-1beta-induced S100B secretion is a component of the neuroinflammatory response, which would support the involvement of S100B in the genesis of neurodegenerative diseases.

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Year:  2008        PMID： 19042033     DOI： 10.1016/j.jneuroim.2008.10.012

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  31 in total

1.  S100B secretion in acute brain slices: modulation by extracellular levels of Ca(2+) and K (+).

Authors:  Patrícia Nardin; Lucas Tortorelli; André Quincozes-Santos; Lúcia Maria V de Almeida; Marina C Leite; Ana Paula Thomazi; Carmem Gottfried; Susana T Wofchuk; Rosario Donato; Carlos-Alberto Gonçalves
Journal:  Neurochem Res       Date:  2009-03-15       Impact factor: 3.996

2.  Methylglyoxal alters glucose metabolism and increases AGEs content in C6 glioma cells.

Authors:  Fernanda Hansen; Daniela Fraga de Souza; Simone da Luz Silveira; Ana Lúcia Hoefel; Júlia Bijoldo Fontoura; Ana Carolina Tramontina; Larissa Daniele Bobermin; Marina Concli Leite; Marcos Luiz Santos Perry; Carlos Alberto Gonçalves
Journal:  Metab Brain Dis       Date:  2012-07-18       Impact factor: 3.584

3.  Peripheral Levels of AGEs and Astrocyte Alterations in the Hippocampus of STZ-Diabetic Rats.

Authors:  Patrícia Nardin; Caroline Zanotto; Fernanda Hansen; Cristiane Batassini; Manuela Sangalli Gasparin; Patrícia Sesterheim; Carlos-Alberto Gonçalves
Journal:  Neurochem Res       Date:  2016-04-15       Impact factor: 3.996

4.  Insulin Stimulates S100B Secretion and These Proteins Antagonistically Modulate Brain Glucose Metabolism.

Authors:  Krista Minéia Wartchow; Ana Carolina Tramontina; Daniela F de Souza; Regina Biasibetti; Larissa D Bobermin; Carlos-Alberto Gonçalves
Journal:  Neurochem Res       Date:  2016-02-15       Impact factor: 3.996

5.  S100B protein in tissue development, repair and regeneration.

Authors:  Guglielmo Sorci; Francesca Riuzzi; Cataldo Arcuri; Claudia Tubaro; Roberta Bianchi; Ileana Giambanco; Rosario Donato
Journal:  World J Biol Chem       Date:  2013-02-26

6.  S100B Protein, A Damage-Associated Molecular Pattern Protein in the Brain and Heart, and Beyond.

Authors:  Guglielmo Sorci; Roberta Bianchi; Francesca Riuzzi; Claudia Tubaro; Cataldo Arcuri; Ileana Giambanco; Rosario Donato
Journal:  Cardiovasc Psychiatry Neurol       Date:  2010-08-18

7.  The S100B/RAGE Axis in Alzheimer's Disease.

Authors:  Estelle Leclerc; Emmanuel Sturchler; Stefan W Vetter
Journal:  Cardiovasc Psychiatry Neurol       Date:  2010-06-21

8.  Short-Term Alterations in Behavior and Astroglial Function After Intracerebroventricular Infusion of Methylglyoxal in Rats.

Authors:  Lílian Juliana Lissner; Leticia Rodrigues; Krista Minéia Wartchow; Ederson Borba; Larissa Daniele Bobermin; Fernanda Urruth Fontella; Fernanda Hansen; André Quincozes-Santos; Diogo Onofre Gomes Souza; Carlos-Alberto Gonçalves
Journal:  Neurochem Res       Date:  2020-10-23       Impact factor: 3.996

Review 9.  Functions of S100 proteins.

Authors:  R Donato; B R Cannon; G Sorci; F Riuzzi; K Hsu; D J Weber; C L Geczy
Journal:  Curr Mol Med       Date:  2013-01       Impact factor: 2.222

10.  High S100B levels in cerebrospinal fluid and peripheral blood of patients with acute basal ganglial hemorrhage are associated with poor outcome.

Authors:  Man Huang; Xiao-Qiao Dong; Yue-Yu Hu; Wen-Hua Yu; Zu-Yong Zhang
Journal:  World J Emerg Med       Date:  2010
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