| Literature DB >> 19041745 |
Jan Vijg1, Alexander Y Maslov, Yousin Suh.
Abstract
The yeast sirtuin (Sir2) is a histone deacetylase that modulates yeast replicative life span by suppressing genome instability through chromatin modification. In this issue, Oberdoerffer et al. (2008) report that SIRT1, the mammalian ortholog of Sir2, is involved in DNA damage-induced chromatin reorganization, which promotes genome stability in mammalian cells.Entities:
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Year: 2008 PMID： 19041745 DOI： 10.1016/j.cell.2008.11.008
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582