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Literature DB >> 19041600

Can we finally target the leukemic stem cells?

Abstract

Two key issues must be addressed in the discussion of targeting leukemic stem cells: (1) can the leukemic stem cell be targeted in vivo, and (2) how to assess whether the leukemic stem cell is actually being targeted. Currently several small molecule and antibody- or ligand-based agents have shown activity in selectively targeting the leukemic stem cell. However, there is debate about how to use these targeted agents and how to identify and quantitate the leukemic stem cell to determine whether or not it is being targeted. Parameters are suggested here to help identify and quantitate leukemic stem cells in the clinical context.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
Biomarkers

Year: 2008 PMID： 19041600 PMCID： PMC2613248 DOI： 10.1016/j.beha.2008.07.006

Source DB: PubMed Journal: Best Pract Res Clin Haematol ISSN： 1521-6926 Impact factor: 3.020

14 in total

1. Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia.

Authors: Marina Konopleva; Rooha Contractor; Twee Tsao; Ismael Samudio; Peter P Ruvolo; Shinichi Kitada; Xingming Deng; Dayong Zhai; Yue-Xi Shi; Thomas Sneed; Monique Verhaegen; Maria Soengas; Vivian R Ruvolo; Teresa McQueen; Wendy D Schober; Julie C Watt; Tilahun Jiffar; Xiaoyang Ling; Frank C Marini; David Harris; Martin Dietrich; Zeev Estrov; James McCubrey; W Stratford May; John C Reed; Michael Andreeff
Journal: Cancer Cell Date: 2006-11 Impact factor: 31.743

2. Targeting of CD44 eradicates human acute myeloid leukemic stem cells.

Authors: Liqing Jin; Kristin J Hope; Qiongli Zhai; Florence Smadja-Joffe; John E Dick
Journal: Nat Med Date: 2006-09-24 Impact factor: 53.440

3. The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells.

Authors: Monica L Guzman; Randall M Rossi; Lilliana Karnischky; Xiaojie Li; Derick R Peterson; Dianna S Howard; Craig T Jordan
Journal: Blood Date: 2005-02-01 Impact factor: 22.113

4. Preferential induction of apoptosis for primary human leukemic stem cells.

Authors: Monica L Guzman; Carol F Swiderski; Dianna S Howard; Barry A Grimes; Randall M Rossi; Stephen J Szilvassy; Craig T Jordan
Journal: Proc Natl Acad Sci U S A Date: 2002-11-25 Impact factor: 11.205

5. CD96 is a leukemic stem cell-specific marker in human acute myeloid leukemia.

Authors: Naoki Hosen; Christopher Y Park; Naoya Tatsumi; Yusuke Oji; Haruo Sugiyama; Martin Gramatzki; Alan M Krensky; Irving L Weissman
Journal: Proc Natl Acad Sci U S A Date: 2007-06-18 Impact factor: 11.205

6. CXCR4 regulates migration and development of human acute myelogenous leukemia stem cells in transplanted NOD/SCID mice.

Authors: Sigal Tavor; Isabelle Petit; Svetlana Porozov; Abraham Avigdor; Ayelet Dar; Leonor Leider-Trejo; Noga Shemtov; Varda Deutsch; Ella Naparstek; Arnon Nagler; Tsvee Lapidot
Journal: Cancer Res Date: 2004-04-15 Impact factor: 12.701

7. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice.

Authors: T Lapidot; C Sirard; J Vormoor; B Murdoch; T Hoang; J Caceres-Cortes; M Minden; B Paterson; M A Caligiuri; J E Dick
Journal: Nature Date: 1994-02-17 Impact factor: 49.962

8. An orally bioavailable parthenolide analog selectively eradicates acute myelogenous leukemia stem and progenitor cells.

Authors: Monica L Guzman; Randall M Rossi; Sundar Neelakantan; Xiaojie Li; Cheryl A Corbett; Duane C Hassane; Michael W Becker; John M Bennett; Edmund Sullivan; Joshua L Lachowicz; Andrew Vaughan; Christopher J Sweeney; William Matthews; Martin Carroll; Jane L Liesveld; Peter A Crooks; Craig T Jordan
Journal: Blood Date: 2007-09-05 Impact factor: 22.113

9. Rapid and selective death of leukemia stem and progenitor cells induced by the compound 4-benzyl, 2-methyl, 1,2,4-thiadiazolidine, 3,5 dione (TDZD-8).

Authors: Monica L Guzman; Xiaojie Li; Cheryl A Corbett; Randall M Rossi; Timothy Bushnell; Jane L Liesveld; Josée Hébert; Fay Young; Craig T Jordan
Journal: Blood Date: 2007-09-04 Impact factor: 22.113

Can we finally target the leukemic stem cells?

1. Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia.

2. Targeting of CD44 eradicates human acute myeloid leukemic stem cells.

3. The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells.

4. Preferential induction of apoptosis for primary human leukemic stem cells.

5. CD96 is a leukemic stem cell-specific marker in human acute myeloid leukemia.

6. CXCR4 regulates migration and development of human acute myelogenous leukemia stem cells in transplanted NOD/SCID mice.

7. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice.

8. An orally bioavailable parthenolide analog selectively eradicates acute myelogenous leukemia stem and progenitor cells.

9. Rapid and selective death of leukemia stem and progenitor cells induced by the compound 4-benzyl, 2-methyl, 1,2,4-thiadiazolidine, 3,5 dione (TDZD-8).

10. Discovery of agents that eradicate leukemia stem cells using an in silico screen of public gene expression data.

1. Extinction models for cancer stem cell therapy.

2. Differential destruction of stem cells: implications for targeted cancer stem cell therapy.

Review 3. Acute myeloid leukemia stem cells: seek and destroy.

Review 4. Curcumin: updated molecular mechanisms and intervention targets in human lung cancer.

5. Prostate epithelial stem cells are resistant to apoptosis after α1-antagonist treatment. The impact for BPH patients.