Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Phosphorylation of DeltaFosB mediates its stability in vivo.

Literature DB >> 19041372

Phosphorylation of DeltaFosB mediates its stability in vivo.

P G Ulery-Reynolds¹, M A Castillo, V Vialou, S J Russo, E J Nestler.

Abstract

The transcription factor, DeltaFosB, accumulates in a region-specific manner in brain in response to many types of chronic stimulation due to the unusual stability of the protein. The phosphorylation of Ser27 in DeltaFosB has been shown to promote this stability in vitro. We show here that this phosphorylation reaction is also important for DeltaFosB's stability in the brain in vivo and for the unique behavioral plasticity mediated by this transcription factor.

Entities: Chemical Disease Gene Mutation Species

Mesh：

Substances：

Year: 2008 PMID： 19041372 PMCID： PMC2734485 DOI： 10.1016/j.neuroscience.2008.10.059

Source DB: PubMed Journal: Neuroscience ISSN： 0306-4522 Impact factor: 3.590

25 in total

1. Striatal cell type-specific overexpression of DeltaFosB enhances incentive for cocaine.

Authors: Christina R Colby; Kim Whisler; Cathy Steffen; Eric J Nestler; David W Self
Journal: J Neurosci Date: 2003-03-15 Impact factor: 6.167

Review 2. Immediate-early genes: ten years on.

Authors: J I Morgan; T Curran
Journal: Trends Neurosci Date: 1995-02 Impact factor: 13.837

3. Chronic Fos-related antigens: stable variants of deltaFosB induced in brain by chronic treatments.

Authors: J Chen; M B Kelz; B T Hope; Y Nakabeppu; E J Nestler
Journal: J Neurosci Date: 1997-07-01 Impact factor: 6.167

4. FosB mutant mice: loss of chronic cocaine induction of Fos-related proteins and heightened sensitivity to cocaine's psychomotor and rewarding effects.

Authors: N Hiroi; J R Brown; C N Haile; H Ye; M E Greenberg; E J Nestler
Journal: Proc Natl Acad Sci U S A Date: 1997-09-16 Impact factor: 11.205

Review 5. The neurobiology of slow synaptic transmission.

Authors: P Greengard
Journal: Science Date: 2001-11-02 Impact factor: 47.728

6. Transcription factors involved in the pathogenesis of L-DOPA-induced dyskinesia in a rat model of Parkinson's disease.

Authors: M A Cenci
Journal: Amino Acids Date: 2002 Impact factor: 3.520

7. Essential role for RGS9 in opiate action.

Authors: Venetia Zachariou; Dan Georgescu; Nick Sanchez; Zia Rahman; Ralph DiLeone; Olivier Berton; Rachael L Neve; Laura J Sim-Selley; Dana E Selley; Stephen J Gold; Eric J Nestler
Journal: Proc Natl Acad Sci U S A Date: 2003-10-31 Impact factor: 11.205

8. Delta FosB regulates wheel running.

Authors: Martin Werme; Chad Messer; Lars Olson; Lauren Gilden; Peter Thorén; Eric J Nestler; Stefan Brené
Journal: J Neurosci Date: 2002-09-15 Impact factor: 6.167

9. Phospholipase Cgamma in distinct regions of the ventral tegmental area differentially modulates mood-related behaviors.

Authors: Carlos A Bolaños; Linda I Perrotti; Scott Edwards; Amelia J Eisch; Michel Barrot; Valerie G Olson; David S Russell; Rachael L Neve; Eric J Nestler
Journal: J Neurosci Date: 2003-08-20 Impact factor: 6.167

10. The influence of DeltaFosB in the nucleus accumbens on natural reward-related behavior.

Authors: Deanna L Wallace; Vincent Vialou; Loretta Rios; Tiffany L Carle-Florence; Sumana Chakravarty; Arvind Kumar; Danielle L Graham; Thomas A Green; Anne Kirk; Sergio D Iñiguez; Linda I Perrotti; Michel Barrot; Ralph J DiLeone; Eric J Nestler; Carlos A Bolaños-Guzmán
Journal: J Neurosci Date: 2008-10-08 Impact factor: 6.167

29 in total

1. ΔFosB in the nucleus accumbens is critical for reinforcing effects of sexual reward.

Authors: K K Pitchers; K S Frohmader; V Vialou; E Mouzon; E J Nestler; M N Lehman; L M Coolen
Journal: Genes Brain Behav Date: 2010-08-16 Impact factor: 3.449

Review 2. Emerging role of viral vectors for circuit-specific gene interrogation and manipulation in rodent brain.

Authors: Erika Sarno; Alfred J Robison
Journal: Pharmacol Biochem Behav Date: 2018-04-27 Impact factor: 3.533

3. FosB is essential for the enhancement of stress tolerance and antagonizes locomotor sensitization by ΔFosB.

Authors: Yoshinori N Ohnishi; Yoko H Ohnishi; Masaaki Hokama; Hiroko Nomaru; Katsuhisa Yamazaki; Yohei Tominaga; Kunihiko Sakumi; Eric J Nestler; Yusaku Nakabeppu
Journal: Biol Psychiatry Date: 2011-06-15 Impact factor: 13.382

4. Mechanisms of psychostimulant-induced structural plasticity.

Authors: Sam A Golden; Scott J Russo
Journal: Cold Spring Harb Perspect Med Date: 2012-10-01 Impact factor: 6.915

Review 5. Transcriptional and epigenetic mechanisms of addiction.

Authors: Alfred J Robison; Eric J Nestler
Journal: Nat Rev Neurosci Date: 2011-10-12 Impact factor: 34.870

6. Functional role of the N-terminal domain of ΔFosB in response to stress and drugs of abuse.

Authors: Y N Ohnishi; Y H Ohnishi; V Vialou; E Mouzon; Q LaPlant; A Nishi; E J Nestler
Journal: Neuroscience Date: 2014-10-13 Impact factor: 3.590

7. Threonine 149 phosphorylation enhances ΔFosB transcriptional activity to control psychomotor responses to cocaine.

Authors: Hannah M Cates; Mackenzie Thibault; Madeline Pfau; Elizabeth Heller; Andrew Eagle; Paula Gajewski; Rosemary Bagot; Christopher Colangelo; Thomas Abbott; Gabby Rudenko; Rachael Neve; Eric J Nestler; Alfred J Robison
Journal: J Neurosci Date: 2014-08-20 Impact factor: 6.167

Review 8. ∆FosB: a transcriptional regulator of stress and antidepressant responses.

Authors: Eric J Nestler
Journal: Eur J Pharmacol Date: 2014-11-07 Impact factor: 4.432

Review 9. Experimental psychiatric illness and drug abuse models: from human to animal, an overview.

Authors: Scott Edwards; George F Koob
Journal: Methods Mol Biol Date: 2012

10. Behavioral and structural responses to chronic cocaine require a feedforward loop involving ΔFosB and calcium/calmodulin-dependent protein kinase II in the nucleus accumbens shell.

Authors: Alfred J Robison; Vincent Vialou; Michelle Mazei-Robison; Jian Feng; Saïd Kourrich; Miles Collins; Sunmee Wee; George Koob; Gustavo Turecki; Rachael Neve; Mark Thomas; Eric J Nestler
Journal: J Neurosci Date: 2013-03-06 Impact factor: 6.167