Literature DB >> 19041309

Endogenous microRNAs induced by heat-shock reduce myocardial infarction following ischemia-reperfusion in mice.

Chang Yin1, Xiaoyin Wang, Rakesh C Kukreja.   

Abstract

We investigated the role of microRNAs (miRNA) in protection against ischemia/reperfusion (I/R) injury in heart. Mice subjected to cytoprotective heat-shock (HS) showed a significant increase of miRNA-1, miRNA-21 and miRNA-24 in the heart. miRNAs isolated from HS mice and injected into non-HS mice significantly reduced infarct size after I/R injury, which was associated with the inhibition of pro-apoptotic genes and increase in anti-apoptotic genes. Chemically synthesized miRNA-21 also reduced infarct size, whereas a miRNA-21 inhibitor abolished this effect. Overall, these studies for the first time provide evidence for the potential role of endogenously synthesized miRNA's in cardioprotection following I/R injury.

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Year:  2008        PMID： 19041309      PMCID： PMC3031789          DOI： 10.1016/j.febslet.2008.11.014

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  51 in total

1.  MicroRNA genes are transcribed by RNA polymerase II.

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2.  MicroRNA1 influences cardiac differentiation in Drosophila and regulates Notch signaling.

Authors:  Chulan Kwon; Zhe Han; Eric N Olson; Deepak Srivastava
Journal:  Proc Natl Acad Sci U S A       Date:  2005-12-15       Impact factor: 11.205

3.  Autophagy as a protective response to Bnip3-mediated apoptotic signaling in the heart.

Authors:  Anne Hamacher-Brady; Nathan R Brady; Roberta A Gottlieb; Asa B Gustafsson
Journal:  Autophagy       Date:  2006-10-25       Impact factor: 16.016

4.  Myogenic factors that regulate expression of muscle-specific microRNAs.

Authors:  Prakash K Rao; Roshan M Kumar; Mina Farkhondeh; Scott Baskerville; Harvey F Lodish
Journal:  Proc Natl Acad Sci U S A       Date:  2006-05-26       Impact factor: 11.205

5.  Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis.

Authors:  Yong Zhao; Eva Samal; Deepak Srivastava
Journal:  Nature       Date:  2005-07-14       Impact factor: 49.962

6.  Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs.

Authors:  Lee P Lim; Nelson C Lau; Philip Garrett-Engele; Andrew Grimson; Janell M Schelter; John Castle; David P Bartel; Peter S Linsley; Jason M Johnson
Journal:  Nature       Date:  2005-01-30       Impact factor: 49.962

7.  Mesodermally expressed Drosophila microRNA-1 is regulated by Twist and is required in muscles during larval growth.

Authors:  Nicholas S Sokol; Victor Ambros
Journal:  Genes Dev       Date:  2005-09-15       Impact factor: 11.361

8.  miR-15 and miR-16 induce apoptosis by targeting BCL2.

Authors:  Amelia Cimmino; George Adrian Calin; Muller Fabbri; Marilena V Iorio; Manuela Ferracin; Masayoshi Shimizu; Sylwia E Wojcik; Rami I Aqeilan; Simona Zupo; Mariella Dono; Laura Rassenti; Hansjuerg Alder; Stefano Volinia; Chang-Gong Liu; Thomas J Kipps; Massimo Negrini; Carlo M Croce
Journal:  Proc Natl Acad Sci U S A       Date:  2005-09-15       Impact factor: 11.205

9.  The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation.

Authors:  Jian-Fu Chen; Elizabeth M Mandel; J Michael Thomson; Qiulian Wu; Thomas E Callis; Scott M Hammond; Frank L Conlon; Da-Zhi Wang
Journal:  Nat Genet       Date:  2005-12-25       Impact factor: 38.330

10.  MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells.

Authors:  Jennifer A Chan; Anna M Krichevsky; Kenneth S Kosik
Journal:  Cancer Res       Date:  2005-07-15       Impact factor: 12.701
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  51 in total

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Authors:  R Madhyastha; H Madhyastha; Y Nakajima; S Omura; M Maruyama
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Review 2.  Non-coding RNAs turn up the heat: an emerging layer of novel regulators in the mammalian heat shock response.

Authors:  Robert F Place; Emily J Noonan
Journal:  Cell Stress Chaperones       Date:  2013-09-04       Impact factor: 3.667

Review 3.  MicroRNAs: a novel class of potential therapeutic targets for cardiovascular diseases.

Authors:  Zhen-wei Pan; Yan-jie Lu; Bao-feng Yang
Journal:  Acta Pharmacol Sin       Date:  2009-12-07       Impact factor: 6.150

Review 4.  Non-coding RNAs as regulators of gene expression and epigenetics.

Authors:  Minna U Kaikkonen; Michael T Y Lam; Christopher K Glass
Journal:  Cardiovasc Res       Date:  2011-05-09       Impact factor: 10.787

5.  Ischaemic preconditioning-regulated miR-21 protects heart against ischaemia/reperfusion injury via anti-apoptosis through its target PDCD4.

Authors:  Yunhui Cheng; Ping Zhu; Jian Yang; Xiaojun Liu; Shimin Dong; Xiaobin Wang; Bao Chun; Jian Zhuang; Chunxiang Zhang
Journal:  Cardiovasc Res       Date:  2010-03-10       Impact factor: 10.787

Review 6.  Myocardial AKT: the omnipresent nexus.

Authors:  Mark A Sussman; Mirko Völkers; Kimberlee Fischer; Brandi Bailey; Christopher T Cottage; Shabana Din; Natalie Gude; Daniele Avitabile; Roberto Alvarez; Balaji Sundararaman; Pearl Quijada; Matt Mason; Mathias H Konstandin; Amy Malhowski; Zhaokang Cheng; Mohsin Khan; Michael McGregor
Journal:  Physiol Rev       Date:  2011-07       Impact factor: 37.312

7.  The dynamic stress-induced "O-GlcNAc-ome" highlights functions for O-GlcNAc in regulating DNA damage/repair and other cellular pathways.

Authors:  Natasha E Zachara; Henrik Molina; Ker Yi Wong; Akhilesh Pandey; Gerald W Hart
Journal:  Amino Acids       Date:  2010-07-31       Impact factor: 3.520

8.  MicroRNA expression in response to murine myocardial infarction: miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue.

Authors:  Sashwati Roy; Savita Khanna; Syed-Rehan A Hussain; Sabyasachi Biswas; Ali Azad; Cameron Rink; Surya Gnyawali; Shani Shilo; Gerard J Nuovo; Chandan K Sen
Journal:  Cardiovasc Res       Date:  2009-01-15       Impact factor: 10.787

9.  A novel role of microRNA in late preconditioning: upregulation of endothelial nitric oxide synthase and heat shock protein 70.

Authors:  Chang Yin; Fadi N Salloum; Rakesh C Kukreja
Journal:  Circ Res       Date:  2009-02-12       Impact factor: 17.367

10.  MicroRNA profiling in ischemic injury of the gracilis muscle in rats.

Authors:  Ching-Hua Hsieh; Jonathan Chris Jeng; Seng-Feng Jeng; Chia-Jung Wu; Tsu-Hsiang Lu; Po-Chou Liliang; Cheng-Shyuan Rau; Yi-Chun Chen; Chia-Jung Lin
Journal:  BMC Musculoskelet Disord       Date:  2010-06-17       Impact factor: 2.362
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