Management of regional metastases in well-differentiated thyroid cancer.

Thyroid cancer represents the most common endocrine cancer, and rates have been increasing over the last 3 decades. The treatment of cervical metastases in well differentiated thyroid cancer remains in evolution. Many questions require further resolution. Unlike many other malignancies, most large studies have found that overall survival is not significantly affected by regional metastases. On the other hand, several studies have noted that regional disease may decrease survival in selected patient groups. The greatest effect of lymph node metastases seems to be an increase in recurrence rates. Except for the compartment-oriented removal of clinically positive nodes, few strong recommendations may be made.