OBJECTIVE: To identify male patients who were treated with infliximab and had fathered healthy newborns during their management. METHODS: We reviewed medical records of men with ankylosing spondylitis (AS) who were followed up at the Rheumatology Outpatients clinic and were treated with infliximab during the period 2001-2007. RESULTS: We identified 4 patients with AS who had fathered 6 healthy children during infliximab treatment. One patient was also treated with small doses of methotrexate. CONCLUSION: Limited data are available concerning the effects of infliximab on semen quality. Our cases provide some evidence or reassurance for male patients treated with the anti-tumor necrosis factor-alpha agent. Further prospective studies are necessary, however, to guide clinicians in decision making.
OBJECTIVE: To identify male patients who were treated with infliximab and had fathered healthy newborns during their management. METHODS: We reviewed medical records of men with ankylosing spondylitis (AS) who were followed up at the Rheumatology Outpatients clinic and were treated with infliximab during the period 2001-2007. RESULTS: We identified 4 patients with AS who had fathered 6 healthy children during infliximab treatment. One patient was also treated with small doses of methotrexate. CONCLUSION: Limited data are available concerning the effects of infliximab on semen quality. Our cases provide some evidence or reassurance for male patients treated with the anti-tumornecrosis factor-alpha agent. Further prospective studies are necessary, however, to guide clinicians in decision making.
Authors: Stefano Palomba; Giuliana Sereni; Angela Falbo; Marina Beltrami; Silvia Lombardini; Maria Chiara Boni; Giovanni Fornaciari; Romano Sassatelli; Giovanni Battista La Sala Journal: World J Gastroenterol Date: 2014-06-21 Impact factor: 5.742