Literature DB >> 19039627

Early development of human hematopoietic and acquired immune systems in new born NOD/Scid/Jak3null mice intrahepatic engrafted with cord blood-derived CD34 + cells.

Seiji Okada1, Hideki Harada2, Takaaki Ito3, Takashi Saito4, Shinya Suzu2.   

Abstract

An animal model in which the human immune system can be reconstituted is necessary to study acquired immunity in vivo. We report here a novel model, the NOD/SCID/JAK3(null) mouse, for the human immune system's development. Newborn mice transplanted with human cord blood CD34(+) cells intrahepatically, developed human T and B cells, and myeloid and plasmacytoid dendritic cells. The T and B cells had a naïve to memory phenotype, and included plasma cells. The human acquired immune system can be reconstituted from CD34(+) cells in NOD/SCID/JAK3(null) mice. This model is a powerful tool for the study of human immunity.

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Year:  2008        PMID： 19039627     DOI： 10.1007/s12185-008-0215-z

Source DB:  PubMed          Journal:  Int J Hematol        ISSN： 0925-5710            Impact factor:   2.490


  23 in total

1.  Development of a human adaptive immune system in cord blood cell-transplanted mice.

Authors:  Elisabetta Traggiai; Laurie Chicha; Luca Mazzucchelli; Lucio Bronz; Jean-Claude Piffaretti; Antonio Lanzavecchia; Markus G Manz
Journal:  Science       Date:  2004-04-02       Impact factor: 47.728

2.  Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chain(null) mice.

Authors:  Fumihiko Ishikawa; Masaki Yasukawa; Bonnie Lyons; Shuro Yoshida; Toshihiro Miyamoto; Goichi Yoshimoto; Takeshi Watanabe; Koichi Akashi; Leonard D Shultz; Mine Harada
Journal:  Blood       Date:  2005-05-26       Impact factor: 22.113

3.  Disseminated and sustained HIV infection in CD34+ cord blood cell-transplanted Rag2-/-gamma c-/- mice.

Authors:  Stefan Baenziger; Roxane Tussiwand; Erika Schlaepfer; Luca Mazzucchelli; Mathias Heikenwalder; Michael O Kurrer; Silvia Behnke; Joachim Frey; Annette Oxenius; Helen Joller; Adriano Aguzzi; Markus G Manz; Roberto F Speck
Journal:  Proc Natl Acad Sci U S A       Date:  2006-10-12       Impact factor: 11.205

4.  Bm1-Bm5 classification of peripheral blood B cells reveals circulating germinal center founder cells in healthy individuals and disturbance in the B cell subpopulations in patients with primary Sjögren's syndrome.

Authors:  J Ø Bohnhorst; M B Bjørgan; J E Thoen; J B Natvig; K M Thompson
Journal:  J Immunol       Date:  2001-10-01       Impact factor: 5.422

5.  Hematopoietic stem cell-engrafted NOD/SCID/IL2Rgamma null mice develop human lymphoid systems and induce long-lasting HIV-1 infection with specific humoral immune responses.

Authors:  Satoru Watanabe; Kazuo Terashima; Shinrai Ohta; Shigeo Horibata; Misako Yajima; Yoko Shiozawa; M Zahidunnabi Dewan; Zhong Yu; Mamoru Ito; Tomohiro Morio; Norio Shimizu; Mitsuo Honda; Naoki Yamamoto
Journal:  Blood       Date:  2006-09-05       Impact factor: 22.113

6.  Use of a novel chimeric mouse model with a functionally active human immune system to study human immunodeficiency virus type 1 infection.

Authors:  Dong Sung An; Betty Poon; Raphael Ho Tsong Fang; Kees Weijer; Bianca Blom; Hergen Spits; Irvin S Y Chen; Christel H Uittenbogaart
Journal:  Clin Vaccine Immunol       Date:  2007-02-21

7.  A flow-cytometric NK-cytotoxicity assay adapted for use in rat repeated dose toxicity studies.

Authors:  Maritha Marcusson-Ståhl; Karin Cederbrant
Journal:  Toxicology       Date:  2003-12-01       Impact factor: 4.221

8.  Functional human T lymphocyte development from cord blood CD34+ cells in nonobese diabetic/Shi-scid, IL-2 receptor gamma null mice.

Authors:  Takashi Yahata; Kiyoshi Ando; Yoshihiko Nakamura; Yoshito Ueyama; Kazuo Shimamura; Norikazu Tamaoki; Shunichi Kato; Tomomitsu Hotta
Journal:  J Immunol       Date:  2002-07-01       Impact factor: 5.422

9.  Humanized NOD/SCID/IL2Rgamma(null) mice transplanted with hematopoietic stem cells under nonmyeloablative conditions show prolonged life spans and allow detailed analysis of human immunodeficiency virus type 1 pathogenesis.

Authors:  Satoru Watanabe; Shinrai Ohta; Misako Yajima; Kazuo Terashima; Mamoru Ito; Hideo Mugishima; Shigeyoshi Fujiwara; Kazufumi Shimizu; Mitsuo Honda; Norio Shimizu; Naoki Yamamoto
Journal:  J Virol       Date:  2007-09-19       Impact factor: 5.103

10.  Humanized mice: are we there yet?

Authors:  Francesca Macchiarini; Markus G Manz; A Karolina Palucka; Leonard D Shultz
Journal:  J Exp Med       Date:  2005-11-21       Impact factor: 14.307
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  29 in total

1.  Boosting of post-exposure human T-cell and B-cell recall responses in vivo by Burkholderia pseudomallei-related proteins.

Authors:  Arnone Nithichanon; Louise J Gourlay; Gregory J Bancroft; Manabu Ato; Yoshimasa Takahashi; Ganjana Lertmemongkolchai
Journal:  Immunology       Date:  2017-02-09       Impact factor: 7.397

2.  TET2-dependent IL-6 induction mediated by the tumor microenvironment promotes tumor metastasis in osteosarcoma.

Authors:  Hitoshi Itoh; Tsuyoshi Kadomatsu; Hironori Tanoue; Masaki Yugami; Keishi Miyata; Motoyoshi Endo; Jun Morinaga; Eisuke Kobayashi; Takeshi Miyamoto; Ryoma Kurahashi; Kazutoyo Terada; Hiroshi Mizuta; Yuichi Oike
Journal:  Oncogene       Date:  2018-03-08       Impact factor: 9.867

Review 3.  Current advances in humanized mouse models.

Authors:  Ryoji Ito; Takeshi Takahashi; Ikumi Katano; Mamoru Ito
Journal:  Cell Mol Immunol       Date:  2012-02-13       Impact factor: 11.530

4.  Perturbation of proteasome function by bortezomib leading to ER stress-induced apoptotic cell death in cholangiocarcinoma.

Authors:  Kulthida Vaeteewoottacharn; Ryusho Kariya; Kouki Matsuda; Manabu Taura; Chaisiri Wongkham; Sopit Wongkham; Seiji Okada
Journal:  J Cancer Res Clin Oncol       Date:  2013-07-23       Impact factor: 4.553

5.  Establishment of a CD4-positive cell line from an AIDS-related primary effusion lymphoma.

Authors:  Hiroki Goto; Yuki Kojima; Hirokazu Nagai; Seiji Okada
Journal:  Int J Hematol       Date:  2013-04-21       Impact factor: 2.490

6.  Raltegravir blocks the infectivity of red-fluorescent-protein (mCherry)-labeled HIV-1JR-FL in the setting of post-exposure prophylaxis in NOD/SCID/Jak3-/- mice transplanted with human PBMCs.

Authors:  Hiromi Ogata-Aoki; Nobuyo Higashi-Kuwata; Shin-Ichiro Hattori; Hironori Hayashi; Matthew Danish; Manabu Aoki; Chiemi Shiotsu; Yumi Hashiguchi; Akinobu Hamada; Hisataka Kobayashi; Hironobu Ihn; Seiji Okada; Hiroaki Mitsuya
Journal:  Antiviral Res       Date:  2017-09-08       Impact factor: 5.970

7.  Potent activity of a nucleoside reverse transcriptase inhibitor, 4'-ethynyl-2-fluoro-2'-deoxyadenosine, against human immunodeficiency virus type 1 infection in a model using human peripheral blood mononuclear cell-transplanted NOD/SCID Janus kinase 3 knockout mice.

Authors:  Shinichiro Hattori; Kazuhiko Ide; Hirotomo Nakata; Hideki Harada; Shinya Suzu; Noriyuki Ashida; Satoru Kohgo; Hiroyuki Hayakawa; Hiroaki Mitsuya; Seiji Okada
Journal:  Antimicrob Agents Chemother       Date:  2009-06-22       Impact factor: 5.191

8.  Human Induced Pluripotent Stem Cell-Derived Podocytes Mature into Vascularized Glomeruli upon Experimental Transplantation.

Authors:  Sazia Sharmin; Atsuhiro Taguchi; Yusuke Kaku; Yasuhiro Yoshimura; Tomoko Ohmori; Tetsushi Sakuma; Masashi Mukoyama; Takashi Yamamoto; Hidetake Kurihara; Ryuichi Nishinakamura
Journal:  J Am Soc Nephrol       Date:  2015-11-19       Impact factor: 10.121

Review 9.  Perspectives on Non-BLT Humanized Mouse Models for Studying HIV Pathogenesis and Therapy.

Authors:  Kazutaka Terahara; Ryutaro Iwabuchi; Yasuko Tsunetsugu-Yokota
Journal:  Viruses       Date:  2021-04-28       Impact factor: 5.048

10.  Expansion of activated memory CD4+ T cells affects infectivity of CCR5-tropic HIV-1 in humanized NOD/SCID/JAK3null mice.

Authors:  Kazutaka Terahara; Masayuki Ishige; Shota Ikeno; Yu-ya Mitsuki; Seiji Okada; Kazuo Kobayashi; Yasuko Tsunetsugu-Yokota
Journal:  PLoS One       Date:  2013-01-02       Impact factor: 3.240
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