Literature DB >> 19037631

A positive inotropic effect of adenosine in cardiac preparations of right atria from diseased human hearts.

Ulrich Gergs1, Peter Boknik, Wilhelm Schmitz, Andreas Simm, Rolf-Edgar Silber, Joachim Neumann.   

Abstract

The actions of adenosine in the human atrium are of clinical relevance, for instance, to stop supraventricular arrhythmias. The purpose of the present study was to re-evaluate the inotropic effect of adenosine in the human atrium. We studied the effect of adenosine (cumulatively applied) on force of contraction in isolated electrically driven right atrial preparations from patients with coronary heart disease undergoing cardiac surgery. It has been known for some time that adenosine via A(1)-adenosine receptors can elicit a negative inotropic effect in human atrial preparations. We report here that in 25% of the patients studied, a positive inotropic effect to adenosine was detectable. The A(1)-adenosine receptor antagonist 1,3-dipropyl-cyclopentyl-xanthine attenuated this effect. Hence, we conclude that at least in some patients, adenosine can lead to a hitherto overlooked positive inotropic effect.

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Year:  2008        PMID： 19037631     DOI： 10.1007/s00210-008-0374-8

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  30 in total

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Journal:  Pflugers Arch       Date:  1986-09       Impact factor: 3.657

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Authors:  M Endoh; M Maruyama; N Taira
Journal:  J Cardiovasc Pharmacol       Date:  1983 Jan-Feb       Impact factor: 3.105

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2.  Phenotyping of Mice with Heart Specific Overexpression of A2A-Adenosine Receptors: Evidence for Cardioprotective Effects of A2A-Adenosine Receptors.

Authors:  Peter Boknik; Katharina Drzewiecki; John Eskandar; Ulrich Gergs; Stephanie Grote-Wessels; Larissa Fabritz; Paulus Kirchhof; Frank U Müller; Frank Stümpel; Wilhelm Schmitz; Norbert Zimmermann; Uwe Kirchhefer; Joachim Neumann
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