| Literature DB >> 19036814 |
Nicola Decaro1, Viviana Mari, Marco Campolo, Alessio Lorusso, Michele Camero, Gabriella Elia, Vito Martella, Paolo Cordioli, Luis Enjuanes, Canio Buonavoglia.
Abstract
Four canine coronavirus type II (CCoV-II) strains were identified in the guts and internal organs of pups which had died of acute gastroenteritis. The CCoV-II strains were strictly related to porcine transmissible gastroenteritis virus (TGEV) in the N-terminal domain of the spike protein, whereas in the other parts of the genome, a higher genetic relatedness to recent CCoV-II isolates was observed. Experimental infection of dogs with a TGEV-like isolate induced mild gastroenteritis without any systemic involvement. By virus neutralization tests, antigenic differences between reference and TGEV-like CCoVs were found. Our data support the potential recombinant origin of the TGEV-like CCoVs.Entities:
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Year: 2008 PMID： 19036814 PMCID： PMC2620906 DOI： 10.1128/JVI.01937-08
Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103