OBJECTIVE: To investigate the cognitive functioning of low-risk singletons born after intracytoplasmic sperm injection (ICSI) or in vitro fertilization (IVF) at the age of 5 or 10 years. METHODS: Sixty-nine children (35 ICSI, 34 IVF) participated voluntarily in the study that had been approved by the local IRB. Their intellectual functioning was examined by the Kaufmann Assessment Battery for Children. RESULTS: The IQ of the study group fell in the normal range (mean = 98.2; SD = 12.2). ICSI children (IQ = 94.1, SD = 13.8) had statistically lower intellectual abilities compared to IVF children (IQ = 102.0, SD = 9.1; t = -2.81, p = .005), especially in simultaneous mental processing. 23.5% ICSI children, but only 2.9% IVF children (p = .011) had at least borderline delayed cognitive development. CONCLUSIONS: Most artificially conceived singletons show a normal cognitive development, however the method of fertilization seems to have an impact on their IQ. ICSI might be associated with the risk for a slightly delayed cognitive development compared to IVF.
OBJECTIVE: To investigate the cognitive functioning of low-risk singletons born after intracytoplasmic sperm injection (ICSI) or in vitro fertilization (IVF) at the age of 5 or 10 years. METHODS: Sixty-nine children (35 ICSI, 34 IVF) participated voluntarily in the study that had been approved by the local IRB. Their intellectual functioning was examined by the Kaufmann Assessment Battery for Children. RESULTS: The IQ of the study group fell in the normal range (mean = 98.2; SD = 12.2). ICSI children (IQ = 94.1, SD = 13.8) had statistically lower intellectual abilities compared to IVFchildren (IQ = 102.0, SD = 9.1; t = -2.81, p = .005), especially in simultaneous mental processing. 23.5% ICSI children, but only 2.9% IVFchildren (p = .011) had at least borderline delayed cognitive development. CONCLUSIONS: Most artificially conceived singletons show a normal cognitive development, however the method of fertilization seems to have an impact on their IQ. ICSI might be associated with the risk for a slightly delayed cognitive development compared to IVF.
Authors: Monica Mainigi; Jason M Rosenzweig; Jun Lei; Virginia Mensah; Lauren Thomaier; C Conover Talbot; Devvora Olalere; Teri Ord; Rayyan Rozzah; Michael V Johnston; Irina Burd Journal: Reprod Sci Date: 2015-11-26 Impact factor: 3.060