| Literature DB >> 19036641 |
Matthijs C Brouwer1, Jan de Gans, Sebastiaan G B Heckenberg, Aeilko H Zwinderman, Tom van der Poll, Diederik van de Beek.
Abstract
Streptococcus pneumoniae and Neisseria meningitidis can cause sepsis and meningitis. Several risk factors for pneumococcal and meningococcal disease have been identified, but the cause of basic differences in susceptibility between individuals and populations is unknown. Single-nucleotide polymorphisms are thought to explain interindividual differences in susceptibility. New technologies provide the opportunity to study the genetic basis of susceptibility to these diseases. In recent years, several studies have been published on these polymorphisms in pneumococcal and meningococcal disease, many with apparently conflicting results. Herein we provide a systematic overview of all polymorphisms studied for a relation with susceptibility to pneumococcal and meningococcal disease. We also propose an initiative to pool genetic data on pneumococcal and meningococcal meningitis in one biobank.Entities:
Mesh：
Year: 2008 PMID： 19036641 DOI： 10.1016/S1473-3099(08)70261-5
Source DB: PubMed Journal: Lancet Infect Dis ISSN： 1473-3099 Impact factor: 25.071