OBJECTIVE: To assess the neurodevelopmental outcome at 2 years of age of children who had been small-for-gestational-age (SGA) term babies with cerebral blood flow redistribution. METHODS: Perinatal outcome was assessed in a cohort of 97 term singleton appropriate-for-gestational-age and 125 term singleton SGA fetuses with normal umbilical artery Doppler, stratified according to the presence of cerebral blood flow redistribution. Neurodevelopmental outcome was assessed prospectively at 2 years of age by means of the 24-month Age & Stage Questionnaire (ASQ). RESULTS: Of the 125 SGA fetuses, 25 had redistribution of the cerebral blood flow, and 100 did not. There were no significant differences in perinatal outcome between these two SGA groups. At 2 years of age, children who had been SGA fetuses with middle cerebral artery (MCA) pulsatility index (PI) < 5(th) centile had a higher incidence of suboptimal neurodevelopmental outcome compared with those with normal MCA-PI (52% vs. 31%; P = 0.049) and a lower mean centile in communication (53.1 vs. 67.4; P = 0.006) and problem-solving (39.7 vs. 47.4; P = 0.04) areas. CONCLUSION: SGA fetuses with cerebral blood flow redistribution have a higher risk of subtle neurodevelopmental deficits at 2 years of age. This challenges the concept that fetal cerebral redistribution is an entirely protective mechanism and suggests MCA-PI as a risk stratifying factor for adverse neurodevelopmental outcome. (c) 2008 ISUOG.
OBJECTIVE: To assess the neurodevelopmental outcome at 2 years of age of children who had been small-for-gestational-age (SGA) term babies with cerebral blood flow redistribution. METHODS: Perinatal outcome was assessed in a cohort of 97 term singleton appropriate-for-gestational-age and 125 term singleton SGA fetuses with normal umbilical artery Doppler, stratified according to the presence of cerebral blood flow redistribution. Neurodevelopmental outcome was assessed prospectively at 2 years of age by means of the 24-month Age & Stage Questionnaire (ASQ). RESULTS: Of the 125 SGA fetuses, 25 had redistribution of the cerebral blood flow, and 100 did not. There were no significant differences in perinatal outcome between these two SGA groups. At 2 years of age, children who had been SGA fetuses with middle cerebral artery (MCA) pulsatility index (PI) < 5(th) centile had a higher incidence of suboptimal neurodevelopmental outcome compared with those with normal MCA-PI (52% vs. 31%; P = 0.049) and a lower mean centile in communication (53.1 vs. 67.4; P = 0.006) and problem-solving (39.7 vs. 47.4; P = 0.04) areas. CONCLUSION: SGA fetuses with cerebral blood flow redistribution have a higher risk of subtle neurodevelopmental deficits at 2 years of age. This challenges the concept that fetal cerebral redistribution is an entirely protective mechanism and suggests MCA-PI as a risk stratifying factor for adverse neurodevelopmental outcome. (c) 2008 ISUOG.
Authors: Mark A Fogel; Christine Li; Felice Wilson; Tom Pawlowski; Susan C Nicolson; Lisa M Montenegro; Laura Diaz Berenstein; Thomas L Spray; J William Gaynor; Stephanie Fuller; Marc S Keller; Matthew A Harris; Kevin K Whitehead; Robert Clancy; Okan Elci; Jim Bethel; Arastoo Vossough; Daniel J Licht Journal: Heart Date: 2015-06-05 Impact factor: 5.994
Authors: V Lepomäki; T Paavilainen; J Matomäki; S Hurme; L Haataja; H Lapinleimu; L Liisa Lehtonen; M Komu; R Parkkola Journal: Pediatr Radiol Date: 2012-03-16
Authors: Nir Melamed; Ahmet Baschat; Yoav Yinon; Apostolos Athanasiadis; Federico Mecacci; Francesc Figueras; Vincenzo Berghella; Amala Nazareth; Muna Tahlak; H David McIntyre; Fabrício Da Silva Costa; Anne B Kihara; Eran Hadar; Fionnuala McAuliffe; Mark Hanson; Ronald C Ma; Rachel Gooden; Eyal Sheiner; Anil Kapur; Hema Divakar; Diogo Ayres-de-Campos; Liran Hiersch; Liona C Poon; John Kingdom; Roberto Romero; Moshe Hod Journal: Int J Gynaecol Obstet Date: 2021-03 Impact factor: 3.561
Authors: Mark A Fogel; Christine Li; Okan U Elci; Tom Pawlowski; Peter J Schwab; Felice Wilson; Susan C Nicolson; Lisa M Montenegro; Laura Diaz; Thomas L Spray; J William Gaynor; Stephanie Fuller; Christopher Mascio; Marc S Keller; Matthew A Harris; Kevin K Whitehead; Jim Bethel; Arastoo Vossough; Daniel J Licht Journal: Circulation Date: 2016-12-28 Impact factor: 29.690
Authors: M López; M Palacio; A Goncé; S Hernàndez; F J Barranco; L García; M Loncà; J O Coll; E Gratacós; F Figueras Journal: Eur J Clin Microbiol Infect Dis Date: 2014-08-09 Impact factor: 3.267