BACKGROUND: Gossypol has recently been identified as a potential anticancer agent. In this study, a novel liposomal formulation is evaluated for delivery of gossypol. MATERIALS AND METHODS: Gossypol was incorporated into liposomes. The liposomes were characterized for physical and chemical properties and for in vitro cytotoxicity. RESULTS: Gossypol was stably encapsulated in these liposomes and exhibited cytotoxicity towards cancer cells. CONCLUSION: Liposomes can be used effectively as gossypol carriers.
BACKGROUND:Gossypol has recently been identified as a potential anticancer agent. In this study, a novel liposomal formulation is evaluated for delivery of gossypol. MATERIALS AND METHODS:Gossypol was incorporated into liposomes. The liposomes were characterized for physical and chemical properties and for in vitro cytotoxicity. RESULTS:Gossypol was stably encapsulated in these liposomes and exhibited cytotoxicity towards cancer cells. CONCLUSION: Liposomes can be used effectively as gossypol carriers.
Authors: Hong Li; Longzhu Piao; Pingping Xu; Weiping Ye; Saiyi Zhong; Shu-Hong Lin; Samuel K Kulp; Yicheng Mao; Youngah Cho; L James Lee; Robert J Lee; Young C Lin Journal: Pharm Res Date: 2011-06-28 Impact factor: 4.200
Authors: Dorota K Flak; Vivian Adamski; Grzegorz Nowaczyk; Kosma Szutkowski; Michael Synowitz; Stefan Jurga; Janka Held-Feindt Journal: Int J Nanomedicine Date: 2020-10-05