Justin-H Nguyen1. 1. Division of Transplant Surgery, Department of Transplantation, Mayo Clinic, 4500 San Pablo Road, Jacksonville, Florida 32224, USA. nguyen.justin@mayo.edu
Abstract
AIM: To distinguish anastomotic from parenchymal leakage at duct-to-mucosa reconstruction of the pancreatic remnant. METHODS: We reviewed the charts of 68 pancreaticod-uodenectomies performed between 5/2000 and 12/2005 with end-to-side duct-to-mucosa pancreatojejunostomy (PJ). The results of pancreatography, as well as peripancreatic drain volumes, and amylase levels were analyzed. RESULTS: Of 68 pancreatojejunostomies, 48 had no leak by pancreatography and had low-drain amylase (normal); eight had no pancreatographic leak but had elevated drain amylase (parenchymal leak); and 12 had pancreatographic leak and elevated drain amylase (anastomotic leak). Although drain volumes in the parenchymal leak group were significantly elevated at postoperative day (POD) 4, no difference was found at POD 7. Drain amylase level was not significantly different at POD 4. In contrast, at POD 7, the anastomotic-leak group had significantly elevated drain amylase level compared with normal and parenchymal-leak groups (14158 +/- 24083 IU/L vs 89 +/- 139 IU/L and 1707 +/- 1515 IU/L, respectively, P = 0.012). CONCLUSION: For pancreatic remnant reconstruction after pancreaticoduodenectomy, a combination of pancreatogram and peripancreatic drain amylase levels can be used to distinguish between parenchymal and anastomotic leakage at pancreatic remnant reconstruction.
AIM: To distinguish anastomotic from parenchymal leakage at duct-to-mucosa reconstruction of the pancreatic remnant. METHODS: We reviewed the charts of 68 pancreaticod-uodenectomies performed between 5/2000 and 12/2005 with end-to-side duct-to-mucosa pancreatojejunostomy (PJ). The results of pancreatography, as well as peripancreatic drain volumes, and amylase levels were analyzed. RESULTS: Of 68 pancreatojejunostomies, 48 had no leak by pancreatography and had low-drain amylase (normal); eight had no pancreatographic leak but had elevated drain amylase (parenchymal leak); and 12 had pancreatographic leak and elevated drain amylase (anastomotic leak). Although drain volumes in the parenchymal leak group were significantly elevated at postoperative day (POD) 4, no difference was found at POD 7. Drain amylase level was not significantly different at POD 4. In contrast, at POD 7, the anastomotic-leak group had significantly elevated drain amylase level compared with normal and parenchymal-leak groups (14158 +/- 24083 IU/L vs 89 +/- 139 IU/L and 1707 +/- 1515 IU/L, respectively, P = 0.012). CONCLUSION: For pancreatic remnant reconstruction after pancreaticoduodenectomy, a combination of pancreatogram and peripancreatic drain amylase levels can be used to distinguish between parenchymal and anastomotic leakage at pancreatic remnant reconstruction.
Authors: S Ohwada; T Ogawa; S Kawate; Y Tanahashi; S Iwazaki; N Tomizawa; T Yamada; T Ohya; Y Morishita Journal: J Am Coll Surg Date: 2001-07 Impact factor: 6.113
Authors: Daniel J Moskovic; Sally E Hodges; Meng-Fen Wu; F Charles Brunicardi; Susan G Hilsenbeck; William E Fisher Journal: HPB (Oxford) Date: 2010-09 Impact factor: 3.647
Authors: Vladimir D Dugalic; Djordje M Knezevic; Vladan N Obradovic; Miroslava G Gojnic-Dugalic; Slavko V Matic; Aleksandra R Pavlovic-Markovic; Predrag D Dugalic; Srbislav M Knezevic Journal: World J Gastroenterol Date: 2014-07-14 Impact factor: 5.742
Authors: Gijs H K Berkelmans; Ewout A Kouwenhoven; Boudewijn J J Smeets; Teus J Weijs; Luis C Silva Corten; Marc J van Det; Grard A P Nieuwenhuijzen; Misha D P Luyer Journal: World J Gastroenterol Date: 2015-08-14 Impact factor: 5.742
Authors: Xi Li; Ricardo Paz-Fumagalli; Weiping Wang; Beau B Toskich; John A Stauffer; Gregory T Frey; J Mark McKinney; Justin H Nguyen Journal: BMC Gastroenterol Date: 2021-01-28 Impact factor: 3.067