Literature DB >> 19034381

Low frequency stimulation of the pedunculopontine nucleus modulates electrical activity of subthalamic neurons in the rat.

Annamaria Capozzo1, Tiziana Florio, Giuseppina Confalone, Daniela Minchella, Paolo Mazzone, Eugenio Scarnati.   

Abstract

Electrical stimulation of the rat pedunculopontine nucleus (PPTg) (<25 Hz) synchronized firing of subthalamic neurons (STN) with each stimulus, and a continuous irregular activity often preceded recovery of burst discharges in control as well as in 6-hydroxydopamine lesioned animals. Firing was blocked both by increasing frequency of stimulation (>50 Hz) and current intensity (>500 microA). The data suggest that clinically relevant frequencies for PPTg deep brain stimulation in Parkinson's disease modulate burst discharges in STN neurons.

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Year:  2008        PMID： 19034381     DOI： 10.1007/s00702-008-0155-z

Source DB:  PubMed          Journal:  J Neural Transm (Vienna)        ISSN： 0300-9564            Impact factor:   3.575


  28 in total

1.  Deep brain stimulation in Parkinson's disease.

Authors:  P Dowsey-Limousin; V Fraix; A L Benabid; P Pollak
Journal:  Funct Neurol       Date:  2001 Jan-Mar

2.  Pedunculopontine stimulation induces prolonged activation of pontine reticular neurons.

Authors:  E Garcia-Rill; R D Skinner; H Miyazato; Y Homma
Journal:  Neuroscience       Date:  2001       Impact factor: 3.590

Review 3.  Projections from basal ganglia to tegmentum: a subcortical route for explaining the pathophysiology of Parkinson's disease signs?

Authors:  P J Delwaide; J L Pepin; V De Pasqua; A M de Noordhout
Journal:  J Neurol       Date:  2000-04       Impact factor: 4.849

4.  The response of subthalamic nucleus neurons to dopamine receptor stimulation in a rodent model of Parkinson's disease.

Authors:  D S Kreiss; C W Mastropietro; S S Rawji; J R Walters
Journal:  J Neurosci       Date:  1997-09-01       Impact factor: 6.167

5.  Bilateral deep brain stimulation of the pedunculopontine and subthalamic nuclei in severe Parkinson's disease.

Authors:  Alessandro Stefani; Andres M Lozano; Antonella Peppe; Paolo Stanzione; Salvatore Galati; Domenicantonio Tropepi; Mariangela Pierantozzi; Livia Brusa; Eugenio Scarnati; Paolo Mazzone
Journal:  Brain       Date:  2007-01-24       Impact factor: 13.501

6.  Single-unit analysis of the pallidum, thalamus and subthalamic nucleus in parkinsonian patients.

Authors:  M Magnin; A Morel; D Jeanmonod
Journal:  Neuroscience       Date:  2000       Impact factor: 3.590

7.  High-frequency stimulation of the subthalamic nucleus modulates the activity of pedunculopontine neurons through direct activation of excitatory fibres as well as through indirect activation of inhibitory pallidal fibres in the rat.

Authors:  Tiziana Florio; Eugenio Scarnati; Giuseppina Confalone; Daniela Minchella; Salvatore Galati; Paolo Stanzione; Alessandro Stefani; Paolo Mazzone
Journal:  Eur J Neurosci       Date:  2007-02       Impact factor: 3.386

8.  Pedunculopontine nucleus stimulation improves akinesia in a Parkinsonian monkey.

Authors:  Ned Jenkinson; Dipankar Nandi; R Chris Miall; John F Stein; Tipu Z Aziz
Journal:  Neuroreport       Date:  2004-12-03       Impact factor: 1.837

9.  Neuronal loss in the pedunculopontine tegmental nucleus in Parkinson disease and in progressive supranuclear palsy.

Authors:  E C Hirsch; A M Graybiel; C Duyckaerts; F Javoy-Agid
Journal:  Proc Natl Acad Sci U S A       Date:  1987-08       Impact factor: 11.205

10.  Auto- and cross-correlation analysis of subthalamic nucleus neuronal activity in neostriatal- and globus pallidal-lesioned rats.

Authors:  L J Ryan; D J Sanders; K B Clark
Journal:  Brain Res       Date:  1992-06-26       Impact factor: 3.252
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  3 in total

1.  Cholinergic and non-cholinergic mesopontine tegmental neurons projecting to the subthalamic nucleus in the rat.

Authors:  Takako Kita; Hitoshi Kita
Journal:  Eur J Neurosci       Date:  2010-12-31       Impact factor: 3.386

Review 2.  Dichotomy between motor and cognitive functions of midbrain cholinergic neurons.

Authors:  Nadine K Gut; Juan Mena-Segovia
Journal:  Neurobiol Dis       Date:  2018-09-10       Impact factor: 5.996

3.  Optimizing a rodent model of Parkinson's disease for exploring the effects and mechanisms of deep brain stimulation.

Authors:  Karl Nowak; Eilhard Mix; Jan Gimsa; Ulf Strauss; Kiran Kumar Sriperumbudur; Reiner Benecke; Ulrike Gimsa
Journal:  Parkinsons Dis       Date:  2011-04-05
  3 in total

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