Literature DB >> 19033231

Mega-dose vitamin C as therapy for human cancer?

Piet Borst.   

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Year:  2008        PMID： 19033231      PMCID： PMC2596258          DOI： 10.1073/pnas.0809328105

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


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  14 in total

1.  Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) induces apoptosis and cell cycle arrest in A549 cells through p53 accumulation via c-Jun NH2-terminal kinase-mediated phosphorylation at serine 15 in vitro and in vivo.

Authors:  Ya-Ling Hsu; Chien-Yu Cho; Po-Lin Kuo; Yu-Ting Huang; Chun-Ching Lin
Journal:  J Pharmacol Exp Ther       Date:  2006-04-21       Impact factor: 4.030

2.  Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) suppresses NF-kappaB activation and NF-kappaB-regulated gene products through modulation of p65 and IkappaBalpha kinase activation, leading to potentiation of apoptosis induced by cytokine and chemotherapeutic agents.

Authors:  Santosh K Sandur; Haruyo Ichikawa; Gautam Sethi; Kwang Seok Ahn; Bharat B Aggarwal
Journal:  J Biol Chem       Date:  2006-04-19       Impact factor: 5.157

3.  High-dose vitamin C therapy: renewed hope or false promise?

Authors:  Sarit Assouline; Wilson H Miller
Journal:  CMAJ       Date:  2006-03-28       Impact factor: 8.262

4.  Vitamin C and cancer.

Authors:  R E Wittes
Journal:  N Engl J Med       Date:  1985-01-17       Impact factor: 91.245

5.  Oxidative stress by ascorbate/menadione association kills K562 human chronic myelogenous leukaemia cells and inhibits its tumour growth in nude mice.

Authors:  Julien Verrax; Julie Stockis; Aurélie Tison; Henryk S Taper; Pedro Buc Calderon
Journal:  Biochem Pharmacol       Date:  2006-07-07       Impact factor: 5.858

6.  Intravenously administered vitamin C as cancer therapy: three cases.

Authors:  Sebastian J Padayatty; Hugh D Riordan; Stephen M Hewitt; Arie Katz; L John Hoffer; Mark Levine
Journal:  CMAJ       Date:  2006-03-28       Impact factor: 8.262

7.  Ascorbate potentiates the cytotoxicity of menadione leading to an oxidative stress that kills cancer cells by a non-apoptotic caspase-3 independent form of cell death.

Authors:  Julien Verrax; Julie Cadrobbi; Carole Marques; Henryk Taper; Yvette Habraken; Jacques Piette; Pedro Buc Calderon
Journal:  Apoptosis       Date:  2004-03       Impact factor: 4.677

8.  Supplemental ascorbate in the supportive treatment of cancer: reevaluation of prolongation of survival times in terminal human cancer.

Authors:  E Cameron; L Pauling
Journal:  Proc Natl Acad Sci U S A       Date:  1978-09       Impact factor: 11.205

9.  Phase I study of mitomycin C and menadione in advanced solid tumors.

Authors:  K A Margolin; S A Akman; L A Leong; R J Morgan; G Somlo; J W Raschko; C Ahn; J H Doroshow
Journal:  Cancer Chemother Pharmacol       Date:  1995       Impact factor: 3.333

10.  Mitomycin C and menadione for the treatment of lung cancer: a phase II trial.

Authors:  M Tetef; K Margolin; C Ahn; S Akman; W Chow; L Leong; R J Morgan; J Raschko; G Somlo; J H Doroshow
Journal:  Invest New Drugs       Date:  1995       Impact factor: 3.850
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  4 in total

Review 1.  Vitamins and prostate cancer risk.

Authors:  Krishna Vanaja Donkena; R Jeffrey Karnes; Charles Y F Young
Journal:  Molecules       Date:  2010-03-12       Impact factor: 4.411

2.  The Interplay of Ascorbic Acid with Quinones-Chelators-Influence on Lipid Peroxidation: Insight into Anticancer Activity.

Authors:  Olga Yu Selyutina; Polina A Kononova; Vladimir E Koshman; Lidiya G Fedenok; Nikolay E Polyakov
Journal:  Antioxidants (Basel)       Date:  2022-02-13

Review 3.  Mechanistic Insights of Chelator Complexes with Essential Transition Metals: Antioxidant/Pro-Oxidant Activity and Applications in Medicine.

Authors:  Viktor A Timoshnikov; Olga Yu Selyutina; Nikolay E Polyakov; Victoria Didichenko; George J Kontoghiorghes
Journal:  Int J Mol Sci       Date:  2022-01-23       Impact factor: 5.923

4.  Redox Interactions of Vitamin C and Iron: Inhibition of the Pro-Oxidant Activity by Deferiprone.

Authors:  Viktor A Timoshnikov; Tatyana V Kobzeva; Nikolay E Polyakov; George J Kontoghiorghes
Journal:  Int J Mol Sci       Date:  2020-05-31       Impact factor: 5.923
  4 in total

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