Literature DB >> 19032945

Epstein-Barr virus-derived EBNA2 regulates STAT3 activation.

Ryuta Muromoto1, Osamu Ikeda, Kanako Okabe, Sumihito Togi, Shinya Kamitani, Masahiro Fujimuro, Shizuko Harada, Kenji Oritani, Tadashi Matsuda.   

Abstract

The Epstein-Barr virus (EBV)-encoded latency protein EBNA2 is a nuclear transcriptional activator that is essential for EBV-induced cellular transformation. Here, we show that EBNA2 interacts with STAT3, a signal transducer for an interleukin-6 family cytokine, and enhances the transcriptional activity of STAT3 by influencing its DNA-binding activity. Furthermore, EBNA2 cooperatively acts on STAT3 activation with LMP1. These data demonstrate that EBNA2 acts as a transcriptional coactivator of STAT3.

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Year:  2008        PMID： 19032945     DOI： 10.1016/j.bbrc.2008.11.053

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  19 in total

1.  The replication and transcription activator of murine gammaherpesvirus 68 cooperatively enhances cytokine-activated, STAT3-mediated gene expression.

Authors:  Hui-Chen Chang Foreman; Julie Armstrong; Alexis L Santana; Laurie T Krug; Nancy C Reich
Journal:  J Biol Chem       Date:  2017-08-15       Impact factor: 5.157

2.  ATM inhibition prevents interleukin-6 from contributing to the proliferation of glioblastoma cells after ionizing radiation.

Authors:  Yi Chieh Lim; Hazel Quek; Carolin Offenhäuser; Shazrul Fazry; Andrew Boyd; Martin Lavin; Tara Roberts; Bryan Day
Journal:  J Neurooncol       Date:  2018-03-21       Impact factor: 4.130

3.  Prevalence and clinical implications of epstein-barr virus infection in de novo diffuse large B-cell lymphoma in Western countries.

Authors:  Chi Young Ok; Ling Li; Zijun Y Xu-Monette; Carlo Visco; Alexander Tzankov; Ganiraju C Manyam; Santiago Montes-Moreno; Karen Dybkaer; Karen Dybaer; April Chiu; Attilio Orazi; Youli Zu; Govind Bhagat; Jiayu Chen; Kristy L Richards; Eric D Hsi; William W L Choi; J Han van Krieken; Jooryung Huh; Weiyun Ai; Maurilio Ponzoni; Andrés J M Ferreri; John P Farnen; Michael B Møller; Carlo E Bueso-Ramos; Roberto N Miranda; Jane N Winter; Miguel A Piris; L Jeffrey Medeiros; Ken H Young
Journal:  Clin Cancer Res       Date:  2014-02-28       Impact factor: 12.531

Review 4.  STATs in cancer inflammation and immunity: a leading role for STAT3.

Authors:  Hua Yu; Drew Pardoll; Richard Jove
Journal:  Nat Rev Cancer       Date:  2009-11       Impact factor: 60.716

5.  Epstein-Barr Virus (EBV) Tegument Protein BGLF2 Suppresses Type I Interferon Signaling To Promote EBV Reactivation.

Authors:  XueQiao Liu; Tomohiko Sadaoka; Tammy Krogmann; Jeffrey I Cohen
Journal:  J Virol       Date:  2020-05-18       Impact factor: 5.103

Review 6.  The Dynamic Interface of Viruses with STATs.

Authors:  Angela R Harrison; Gregory W Moseley
Journal:  J Virol       Date:  2020-10-27       Impact factor: 5.103

7.  Local microbleeding facilitates IL-6- and IL-17-dependent arthritis in the absence of tissue antigen recognition by activated T cells.

Authors:  Masaaki Murakami; Yuko Okuyama; Hideki Ogura; Shogo Asano; Yasunobu Arima; Mineko Tsuruoka; Masaya Harada; Minoru Kanamoto; Yukihisa Sawa; Yoichiro Iwakura; Kiyoshi Takatsu; Daisuke Kamimura; Toshio Hirano
Journal:  J Exp Med       Date:  2011-01-10       Impact factor: 14.307

8.  Ablation of STAT3 in the B Cell Compartment Restricts Gammaherpesvirus Latency In Vivo.

Authors:  Sandeep Steven Reddy; Hui-Chen Chang Foreman; Thubten Ozula Sioux; Gee Ho Park; Valeria Poli; Nancy C Reich; Laurie T Krug
Journal:  mBio       Date:  2016-08-02       Impact factor: 7.867

9.  Activation of the STAT3 Signaling Pathway by the RNA-Dependent RNA Polymerase Protein of Arenavirus.

Authors:  Qingxing Wang; Qilin Xin; Weijuan Shang; Weiwei Wan; Gengfu Xiao; Lei-Ke Zhang
Journal:  Viruses       Date:  2021-05-25       Impact factor: 5.048

10.  A four-step model for the IL-6 amplifier, a regulator of chronic inflammations in tissue-specific MHC class II-associated autoimmune diseases.

Authors:  Masaaki Murakami; Toshio Hirano
Journal:  Front Immunol       Date:  2011-06-16       Impact factor: 7.561
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