OBJECTIVES: Obesity is considered a risk factor for asthma. However, the mechanism that connects the two is not well understood. In this study we investigated the relationship between inflammatory cytokines and acute phase reactants in obesity, and asthma. METHOD: Asthmatic and control subjects were divided into 2 sub-groups: obese and non-obese. Anthropomorphic parameters, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), leptin, tumour necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6) were compared between obese, asthmatics and control subjects of normal weight. Respiratory function tests and allergy skin tests were also performed in the patients with asthma. RESULTS: ESR, CRP, TNF-alpha, IL-6, and leptin levels in obese asthma patients were higher than in the healthy controls (P < 0.01). TNF-alpha, IL-6, and leptin levels were higher in obese asthma patients than in non-obese asthma patients (P < 0.01). Inflammatory markers were related to parameters of obesity. No association was found between allergy test results and obesity (P > 0.05). CONCLUSION: We identified a relationship between acute phase reactants and inflammatory cytokines, and the criteria for obesity in obese asthma patients. Inflammation markers were at their highest levels in obese asthma patients. Leptin levels were considerably higher in obese patients than in normal weight controls. Like obesity, leptin is suggested to play a role in the pathogenesis of asthma.
OBJECTIVES:Obesity is considered a risk factor for asthma. However, the mechanism that connects the two is not well understood. In this study we investigated the relationship between inflammatory cytokines and acute phase reactants in obesity, and asthma. METHOD: Asthmatic and control subjects were divided into 2 sub-groups: obese and non-obese. Anthropomorphic parameters, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), leptin, tumour necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6) were compared between obese, asthmatics and control subjects of normal weight. Respiratory function tests and allergy skin tests were also performed in the patients with asthma. RESULTS: ESR, CRP, TNF-alpha, IL-6, and leptin levels in obese asthmapatients were higher than in the healthy controls (P < 0.01). TNF-alpha, IL-6, and leptin levels were higher in obese asthmapatients than in non-obese asthmapatients (P < 0.01). Inflammatory markers were related to parameters of obesity. No association was found between allergy test results and obesity (P > 0.05). CONCLUSION: We identified a relationship between acute phase reactants and inflammatory cytokines, and the criteria for obesity in obese asthmapatients. Inflammation markers were at their highest levels in obese asthmapatients. Leptin levels were considerably higher in obesepatients than in normal weight controls. Like obesity, leptin is suggested to play a role in the pathogenesis of asthma.
Authors: Oscar L Veiga; Sonia Gómez-Martínez; David Martínez-Gómez; Ariel Villagra; María E Calle; Ascensión Marcos Journal: BMC Public Health Date: 2009-12-19 Impact factor: 3.295
Authors: Frank K Friedenberg; Jitha Rai; Vishwas Vanar; Charles Bongiorno; Deborah B Nelson; Mayur Parepally; Arashdeep Poonia; Amol Sharma; Shaun Gohel; Joel E Richter Journal: Obes Res Clin Pract Date: 2010-10 Impact factor: 2.288
Authors: Frank M Schmidt; Julia Weschenfelder; Christian Sander; Juliane Minkwitz; Julia Thormann; Tobias Chittka; Roland Mergl; Kenneth C Kirkby; Mathias Faßhauer; Michael Stumvoll; Lesca M Holdt; Daniel Teupser; Ulrich Hegerl; Hubertus Himmerich Journal: PLoS One Date: 2015-03-17 Impact factor: 3.240
Authors: Aleksandra Wardzyńska; Małgorzata Pawełczyk; Joanna Rywaniak; Joanna Makowska; Joanna Jamroz-Brzeska; Marek L Kowalski Journal: Respir Res Date: 2021-06-10