Accumulation of cyclic adenosine 3',5'-monophosphate in adult and newborn mouse skin: responses to ischemia and isoproterenol.

Levels of cyclic adenosine 3',5'-monophosphate in adult mouse skin pieces were rapidly increased on incubation at 37 degrees C, or on exposure to isoproterenol. Accumulation of the cyclic nucleotide under both conditions was greatly decreased in newborn mouse skin, or in adult skin treated with the tumor promotor 12-0-tetradecanoyl-phorbol-13-acetate.