Literature DB >> 19032027

(S)-2-amino-6-nitrohexanoic acid binds to human arginase I through multiple nitro-metal coordination interactions in the binuclear manganese cluster.

Tatiana Y Zakharian1, Luigi Di Costanzo, David W Christianson.   

Abstract

The binding affinity of (S)-2-amino-6-nitrohexanoic acid to human arginase I was studied using surface plasmon resonance (K(d) = 60 microM), and the X-ray crystal structure of the enzyme-inhibitor complex was determined at 1.6 A resolution to reveal multiple nitro-metal coordination interactions.

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Year:  2008        PMID： 19032027     DOI： 10.1021/ja807702q

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  6 in total

Review 1.  Targeting Metalloenzymes for Therapeutic Intervention.

Authors:  Allie Y Chen; Rebecca N Adamek; Benjamin L Dick; Cy V Credille; Christine N Morrison; Seth M Cohen
Journal:  Chem Rev       Date:  2018-09-07       Impact factor: 60.622

2.  2-aminoimidazole amino acids as inhibitors of the binuclear manganese metalloenzyme human arginase I.

Authors:  Monica Ilies; Luigi Di Costanzo; Michelle L North; Jeremy A Scott; David W Christianson
Journal:  J Med Chem       Date:  2010-05-27       Impact factor: 7.446

3.  Mechanism of MenE inhibition by acyl-adenylate analogues and discovery of novel antibacterial agents.

Authors:  Joe S Matarlo; Christopher E Evans; Indrajeet Sharma; Lubens J Lavaud; Stephen C Ngo; Roger Shek; Kanagalaghatta R Rajashankar; Jarrod B French; Derek S Tan; Peter J Tonge
Journal:  Biochemistry       Date:  2015-10-15       Impact factor: 3.162

4.  Inhibition of human arginase I by substrate and product analogues.

Authors:  Luigi Di Costanzo; Monica Ilies; Katherine J Thorn; David W Christianson
Journal:  Arch Biochem Biophys       Date:  2010-02-12       Impact factor: 4.013

Review 5.  Arginase as a Potential Biomarker of Disease Progression: A Molecular Imaging Perspective.

Authors:  Gonçalo S Clemente; Aren van Waarde; Inês F Antunes; Alexander Dömling; Philip H Elsinga
Journal:  Int J Mol Sci       Date:  2020-07-25       Impact factor: 5.923

6.  Cinnamide Derivatives as Mammalian Arginase Inhibitors: Synthesis, Biological Evaluation and Molecular Docking.

Authors:  Thanh-Nhat Pham; Simon Bordage; Marc Pudlo; Céline Demougeot; Khac-Minh Thai; Corine Girard-Thernier
Journal:  Int J Mol Sci       Date:  2016-09-29       Impact factor: 5.923
  6 in total

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